Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

J. B A Crusius; F. Canzian; G. Capellá; A. S. Peña; G. Pera; N. Sala; A. Agudo; F. Rico; G. Del Giudice; D. Palli; M. Plebani; H. Boeing; H. B. Bueno-de-Mesquita; F. Carneiro; V. Pala; V. E. Save; P. Vineis; R. Tumino; S. Panico; G. Berglund; J. Manjer; R. Stenling; G. Hallmans; C. Martínez; M. Dorronsoro; A. Barricarte; C. Navarro; J. R. Quirós; N. Allen; T. J. Key; S. Binghan; C. Caldas; J. Linseisen; R. Kaaks; K. Overvad; A. Tjønneland; F. C. Büchner; P. H M Peeters; M. E. Numans; F. Clavel-Chapelon; A. Trichopoulou; E. Lund; M. Jenab; S. Rinaldi; P. Ferrari; E. Riboli; C. A. González

doi:10.1093/annonc/mdn400

Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

J. B A Crusius, F. Canzian, G. Capellá, A. S. Peña, G. Pera, N. Sala, A. Agudo, F. Rico, G. Del Giudice, D. Palli, M. Plebani, H. Boeing, H. B. Bueno-de-Mesquita, F. Carneiro, V. Pala, V. E. Save, P. Vineis, R. Tumino, S. Panico, G. BerglundJ. Manjer, R. Stenling, G. Hallmans, C. Martínez, M. Dorronsoro, A. Barricarte, C. Navarro, J. R. Quirós, N. Allen, T. J. Key, S. Binghan, C. Caldas, J. Linseisen, R. Kaaks, K. Overvad, A. Tjønneland, F. C. Büchner, P. H M Peeters, M. E. Numans, F. Clavel-Chapelon, A. Trichopoulou, E. Lund, M. Jenab, S. Rinaldi, P. Ferrari, E. Riboli, C. A. González

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.

Original language	English
Pages (from-to)	1894-1902
Number of pages	9
Journal	Annals of Oncology
Volume	19
Issue number	11
DOIs	https://doi.org/10.1093/annonc/mdn400
Publication status	Published - 2008

Keywords

Cytokine genes
Gastric carcinoma
Polymorphisms
Severe chronic atrophic gastritis

ASJC Scopus subject areas

Oncology
Hematology

Access to Document

10.1093/annonc/mdn400

Fingerprint Dive into the research topics of 'Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)'. Together they form a unique fingerprint.

Cite this

Crusius, J. B. A., Canzian, F., Capellá, G., Peña, A. S., Pera, G., Sala, N., Agudo, A., Rico, F., Del Giudice, G., Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H. B., Carneiro, F., Pala, V., Save, V. E., Vineis, P., Tumino, R., Panico, S., ... González, C. A. (2008). Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Annals of Oncology, 19(11), 1894-1902. https://doi.org/10.1093/annonc/mdn400

Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). / Crusius, J. B A; Canzian, F.; Capellá, G.; Peña, A. S.; Pera, G.; Sala, N.; Agudo, A.; Rico, F.; Del Giudice, G.; Palli, D.; Plebani, M.; Boeing, H.; Bueno-de-Mesquita, H. B.; Carneiro, F.; Pala, V.; Save, V. E.; Vineis, P.; Tumino, R.; Panico, S.; Berglund, G.; Manjer, J.; Stenling, R.; Hallmans, G.; Martínez, C.; Dorronsoro, M.; Barricarte, A.; Navarro, C.; Quirós, J. R.; Allen, N.; Key, T. J.; Binghan, S.; Caldas, C.; Linseisen, J.; Kaaks, R.; Overvad, K.; Tjønneland, A.; Büchner, F. C.; Peeters, P. H M; Numans, M. E.; Clavel-Chapelon, F.; Trichopoulou, A.; Lund, E.; Jenab, M.; Rinaldi, S.; Ferrari, P.; Riboli, E.; González, C. A.

In: Annals of Oncology, Vol. 19, No. 11, 2008, p. 1894-1902.

Research output: Contribution to journal › Article › peer-review

Crusius, JBA, Canzian, F, Capellá, G, Peña, AS, Pera, G, Sala, N, Agudo, A, Rico, F, Del Giudice, G, Palli, D, Plebani, M, Boeing, H, Bueno-de-Mesquita, HB, Carneiro, F, Pala, V, Save, VE, Vineis, P, Tumino, R, Panico, S, Berglund, G, Manjer, J, Stenling, R, Hallmans, G, Martínez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, JR, Allen, N, Key, TJ, Binghan, S, Caldas, C, Linseisen, J, Kaaks, R, Overvad, K, Tjønneland, A, Büchner, FC, Peeters, PHM, Numans, ME, Clavel-Chapelon, F, Trichopoulou, A, Lund, E, Jenab, M, Rinaldi, S, Ferrari, P, Riboli, E & González, CA 2008, 'Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)', Annals of Oncology, vol. 19, no. 11, pp. 1894-1902. https://doi.org/10.1093/annonc/mdn400

Crusius, J. B A ; Canzian, F. ; Capellá, G. ; Peña, A. S. ; Pera, G. ; Sala, N. ; Agudo, A. ; Rico, F. ; Del Giudice, G. ; Palli, D. ; Plebani, M. ; Boeing, H. ; Bueno-de-Mesquita, H. B. ; Carneiro, F. ; Pala, V. ; Save, V. E. ; Vineis, P. ; Tumino, R. ; Panico, S. ; Berglund, G. ; Manjer, J. ; Stenling, R. ; Hallmans, G. ; Martínez, C. ; Dorronsoro, M. ; Barricarte, A. ; Navarro, C. ; Quirós, J. R. ; Allen, N. ; Key, T. J. ; Binghan, S. ; Caldas, C. ; Linseisen, J. ; Kaaks, R. ; Overvad, K. ; Tjønneland, A. ; Büchner, F. C. ; Peeters, P. H M ; Numans, M. E. ; Clavel-Chapelon, F. ; Trichopoulou, A. ; Lund, E. ; Jenab, M. ; Rinaldi, S. ; Ferrari, P. ; Riboli, E. ; González, C. A. / Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). In: Annals of Oncology. 2008 ; Vol. 19, No. 11. pp. 1894-1902.

@article{60187802787445fbb30c119b963513b5,

title = "Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)",

abstract = "Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.",

keywords = "Cytokine genes, Gastric carcinoma, Polymorphisms, Severe chronic atrophic gastritis",

author = "Crusius, {J. B A} and F. Canzian and G. Capell{\'a} and Pe{\~n}a, {A. S.} and G. Pera and N. Sala and A. Agudo and F. Rico and {Del Giudice}, G. and D. Palli and M. Plebani and H. Boeing and Bueno-de-Mesquita, {H. B.} and F. Carneiro and V. Pala and Save, {V. E.} and P. Vineis and R. Tumino and S. Panico and G. Berglund and J. Manjer and R. Stenling and G. Hallmans and C. Mart{\'i}nez and M. Dorronsoro and A. Barricarte and C. Navarro and Quir{\'o}s, {J. R.} and N. Allen and Key, {T. J.} and S. Binghan and C. Caldas and J. Linseisen and R. Kaaks and K. Overvad and A. Tj{\o}nneland and B{\"u}chner, {F. C.} and Peeters, {P. H M} and Numans, {M. E.} and F. Clavel-Chapelon and A. Trichopoulou and E. Lund and M. Jenab and S. Rinaldi and P. Ferrari and E. Riboli and Gonz{\'a}lez, {C. A.}",

year = "2008",

doi = "10.1093/annonc/mdn400",

language = "English",

volume = "19",

pages = "1894--1902",

journal = "Annals of Oncology",

issn = "0923-7534",

publisher = "NLM (Medline)",

number = "11",

}

TY - JOUR

T1 - Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

AU - Crusius, J. B A

AU - Canzian, F.

AU - Capellá, G.

AU - Peña, A. S.

AU - Pera, G.

AU - Sala, N.

AU - Agudo, A.

AU - Rico, F.

AU - Del Giudice, G.

AU - Palli, D.

AU - Plebani, M.

AU - Boeing, H.

AU - Bueno-de-Mesquita, H. B.

AU - Carneiro, F.

AU - Pala, V.

AU - Save, V. E.

AU - Vineis, P.

AU - Tumino, R.

AU - Panico, S.

AU - Berglund, G.

AU - Manjer, J.

AU - Stenling, R.

AU - Hallmans, G.

AU - Martínez, C.

AU - Dorronsoro, M.

AU - Barricarte, A.

AU - Navarro, C.

AU - Quirós, J. R.

AU - Allen, N.

AU - Key, T. J.

AU - Binghan, S.

AU - Caldas, C.

AU - Linseisen, J.

AU - Kaaks, R.

AU - Overvad, K.

AU - Tjønneland, A.

AU - Büchner, F. C.

AU - Peeters, P. H M

AU - Numans, M. E.

AU - Clavel-Chapelon, F.

AU - Trichopoulou, A.

AU - Lund, E.

AU - Jenab, M.

AU - Rinaldi, S.

AU - Ferrari, P.

AU - Riboli, E.

AU - González, C. A.

PY - 2008

Y1 - 2008

N2 - Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.

AB - Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.

KW - Cytokine genes

KW - Gastric carcinoma

KW - Polymorphisms

KW - Severe chronic atrophic gastritis

UR - http://www.scopus.com/inward/record.url?scp=54949110598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54949110598&partnerID=8YFLogxK

U2 - 10.1093/annonc/mdn400

DO - 10.1093/annonc/mdn400

M3 - Article

C2 - 18628242

AN - SCOPUS:54949110598

VL - 19

SP - 1894

EP - 1902

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 11

ER -