Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

J. B A Crusius; F. Canzian; G. Capellá; A. S. Peña; G. Pera; N. Sala; A. Agudo; F. Rico; G. Del Giudice; D. Palli; M. Plebani; H. Boeing; H. B. Bueno-de-Mesquita; F. Carneiro; V. Pala; V. E. Save; P. Vineis; R. Tumino; S. Panico; G. Berglund; J. Manjer; R. Stenling; G. Hallmans; C. Martínez; M. Dorronsoro; A. Barricarte; C. Navarro; J. R. Quirós; N. Allen; T. J. Key; S. Binghan; C. Caldas; J. Linseisen; R. Kaaks; K. Overvad; A. Tjønneland; F. C. Büchner; P. H M Peeters; M. E. Numans; F. Clavel-Chapelon; A. Trichopoulou; E. Lund; M. Jenab; S. Rinaldi; P. Ferrari; E. Riboli; C. A. González

doi:10.1093/annonc/mdn400

Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

J. B A Crusius, F. Canzian, G. Capellá, A. S. Peña, G. Pera, N. Sala, A. Agudo, F. Rico, G. Del Giudice, D. Palli, M. Plebani, H. Boeing, H. B. Bueno-de-Mesquita, F. Carneiro, V. Pala, V. E. Save, P. Vineis, R. Tumino, S. Panico, G. BerglundJ. Manjer, R. Stenling, G. Hallmans, C. Martínez, M. Dorronsoro, A. Barricarte, C. Navarro, J. R. Quirós, N. Allen, T. J. Key, S. Binghan, C. Caldas, J. Linseisen, R. Kaaks, K. Overvad, A. Tjønneland, F. C. Büchner, P. H M Peeters, M. E. Numans, F. Clavel-Chapelon, A. Trichopoulou, E. Lund, M. Jenab, S. Rinaldi, P. Ferrari, E. Riboli, C. A. González

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article

Abstract

Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.

Original language	English
Pages (from-to)	1894-1902
Number of pages	9
Journal	Annals of Oncology
Volume	19
Issue number	11
DOIs	https://doi.org/10.1093/annonc/mdn400
Publication status	Published - 2008

Keywords

Cytokine genes
Gastric carcinoma
Polymorphisms
Severe chronic atrophic gastritis

ASJC Scopus subject areas

Oncology
Hematology

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10.1093/annonc/mdn400

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Crusius, J. B. A., Canzian, F., Capellá, G., Peña, A. S., Pera, G., Sala, N., Agudo, A., Rico, F., Del Giudice, G., Palli, D., Plebani, M., Boeing, H., Bueno-de-Mesquita, H. B., Carneiro, F., Pala, V., Save, V. E., Vineis, P., Tumino, R., Panico, S., ... González, C. A. (2008). Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Annals of Oncology, 19(11), 1894-1902. https://doi.org/10.1093/annonc/mdn400

Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). / Crusius, J. B A; Canzian, F.; Capellá, G.; Peña, A. S.; Pera, G.; Sala, N.; Agudo, A.; Rico, F.; Del Giudice, G.; Palli, D.; Plebani, M.; Boeing, H.; Bueno-de-Mesquita, H. B.; Carneiro, F.; Pala, V.; Save, V. E.; Vineis, P.; Tumino, R.; Panico, S.; Berglund, G.; Manjer, J.; Stenling, R.; Hallmans, G.; Martínez, C.; Dorronsoro, M.; Barricarte, A.; Navarro, C.; Quirós, J. R.; Allen, N.; Key, T. J.; Binghan, S.; Caldas, C.; Linseisen, J.; Kaaks, R.; Overvad, K.; Tjønneland, A.; Büchner, F. C.; Peeters, P. H M; Numans, M. E.; Clavel-Chapelon, F.; Trichopoulou, A.; Lund, E.; Jenab, M.; Rinaldi, S.; Ferrari, P.; Riboli, E.; González, C. A.

In: Annals of Oncology, Vol. 19, No. 11, 2008, p. 1894-1902.

Research output: Contribution to journal › Article

Crusius, JBA, Canzian, F, Capellá, G, Peña, AS, Pera, G, Sala, N, Agudo, A, Rico, F, Del Giudice, G, Palli, D, Plebani, M, Boeing, H, Bueno-de-Mesquita, HB, Carneiro, F, Pala, V, Save, VE, Vineis, P, Tumino, R, Panico, S, Berglund, G, Manjer, J, Stenling, R, Hallmans, G, Martínez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quirós, JR, Allen, N, Key, TJ, Binghan, S, Caldas, C, Linseisen, J, Kaaks, R, Overvad, K, Tjønneland, A, Büchner, FC, Peeters, PHM, Numans, ME, Clavel-Chapelon, F, Trichopoulou, A, Lund, E, Jenab, M, Rinaldi, S, Ferrari, P, Riboli, E & González, CA 2008, 'Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)', Annals of Oncology, vol. 19, no. 11, pp. 1894-1902. https://doi.org/10.1093/annonc/mdn400

Crusius, J. B A ; Canzian, F. ; Capellá, G. ; Peña, A. S. ; Pera, G. ; Sala, N. ; Agudo, A. ; Rico, F. ; Del Giudice, G. ; Palli, D. ; Plebani, M. ; Boeing, H. ; Bueno-de-Mesquita, H. B. ; Carneiro, F. ; Pala, V. ; Save, V. E. ; Vineis, P. ; Tumino, R. ; Panico, S. ; Berglund, G. ; Manjer, J. ; Stenling, R. ; Hallmans, G. ; Martínez, C. ; Dorronsoro, M. ; Barricarte, A. ; Navarro, C. ; Quirós, J. R. ; Allen, N. ; Key, T. J. ; Binghan, S. ; Caldas, C. ; Linseisen, J. ; Kaaks, R. ; Overvad, K. ; Tjønneland, A. ; Büchner, F. C. ; Peeters, P. H M ; Numans, M. E. ; Clavel-Chapelon, F. ; Trichopoulou, A. ; Lund, E. ; Jenab, M. ; Rinaldi, S. ; Ferrari, P. ; Riboli, E. ; González, C. A. / Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). In: Annals of Oncology. 2008 ; Vol. 19, No. 11. pp. 1894-1902.

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title = "Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)",

abstract = "Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.",

keywords = "Cytokine genes, Gastric carcinoma, Polymorphisms, Severe chronic atrophic gastritis",

author = "Crusius, {J. B A} and F. Canzian and G. Capell{\'a} and Pe{\~n}a, {A. S.} and G. Pera and N. Sala and A. Agudo and F. Rico and {Del Giudice}, G. and D. Palli and M. Plebani and H. Boeing and Bueno-de-Mesquita, {H. B.} and F. Carneiro and V. Pala and Save, {V. E.} and P. Vineis and R. Tumino and S. Panico and G. Berglund and J. Manjer and R. Stenling and G. Hallmans and C. Mart{\'i}nez and M. Dorronsoro and A. Barricarte and C. Navarro and Quir{\'o}s, {J. R.} and N. Allen and Key, {T. J.} and S. Binghan and C. Caldas and J. Linseisen and R. Kaaks and K. Overvad and A. Tj{\o}nneland and B{\"u}chner, {F. C.} and Peeters, {P. H M} and Numans, {M. E.} and F. Clavel-Chapelon and A. Trichopoulou and E. Lund and M. Jenab and S. Rinaldi and P. Ferrari and E. Riboli and Gonz{\'a}lez, {C. A.}",

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doi = "10.1093/annonc/mdn400",

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TY - JOUR

T1 - Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)

AU - Crusius, J. B A

AU - Canzian, F.

AU - Capellá, G.

AU - Peña, A. S.

AU - Pera, G.

AU - Sala, N.

AU - Agudo, A.

AU - Rico, F.

AU - Del Giudice, G.

AU - Palli, D.

AU - Plebani, M.

AU - Boeing, H.

AU - Bueno-de-Mesquita, H. B.

AU - Carneiro, F.

AU - Pala, V.

AU - Save, V. E.

AU - Vineis, P.

AU - Tumino, R.

AU - Panico, S.

AU - Berglund, G.

AU - Manjer, J.

AU - Stenling, R.

AU - Hallmans, G.

AU - Martínez, C.

AU - Dorronsoro, M.

AU - Barricarte, A.

AU - Navarro, C.

AU - Quirós, J. R.

AU - Allen, N.

AU - Key, T. J.

AU - Binghan, S.

AU - Caldas, C.

AU - Linseisen, J.

AU - Kaaks, R.

AU - Overvad, K.

AU - Tjønneland, A.

AU - Büchner, F. C.

AU - Peeters, P. H M

AU - Numans, M. E.

AU - Clavel-Chapelon, F.

AU - Trichopoulou, A.

AU - Lund, E.

AU - Jenab, M.

AU - Rinaldi, S.

AU - Ferrari, P.

AU - Riboli, E.

AU - González, C. A.

PY - 2008

Y1 - 2008

N2 - Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.

AB - Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested case-control study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL) 1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. IL8 -251AA genotype was associated with a decreased risk of Hp(+) non-cardia GC (OR 0.51; 95% CI 0.32-0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B -580C and TNF&-487A alleles did not associate with an increased risk. A moderately increased risk of Hp(+) non-cardia GC for IL4R -29429T variant was observed (OR 1.74; 95% CI 1.15-2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 -251T>A may modify the risk for GC.

KW - Cytokine genes

KW - Gastric carcinoma

KW - Polymorphisms

KW - Severe chronic atrophic gastritis

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U2 - 10.1093/annonc/mdn400

DO - 10.1093/annonc/mdn400

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AN - SCOPUS:54949110598

VL - 19

SP - 1894

EP - 1902

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

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