Cytokine gene transfer in tumor cells as an approach to antitumor therapy

Mario P. Colombo, Stefano Mattei, Giorgio Parmiani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The transfer of cytokine genes into cancer cells, resulting in cytokine release directly at the site of tumor growth, has proven effective in inhibiting tumor growth in the absence of any toxic effect. Some cytokines induce tumor suppression even in T-cell-deficient mice, suggesting their potential therapeutic effect in poorly immunogenic tumors; other cytokines induce memory T cells that protect mice from subsequent tumor injection. The effects of cytokine genes transferred into tumor cells are summarized and implications discussed.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Volume21
Issue number2-4
DOIs
Publication statusPublished - Jun 1992

Fingerprint

Gene transfer
Tumors
Cells
Cytokines
Genes
Neoplasms
T-cells
Therapeutics
T-Lymphocytes
Poisons
Neoplasm Genes
Therapeutic Uses
Growth
Data storage equipment
Injections

Keywords

  • Cytokines
  • Gene transfer
  • Tumor immunity

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Cytokine gene transfer in tumor cells as an approach to antitumor therapy. / Colombo, Mario P.; Mattei, Stefano; Parmiani, Giorgio.

In: International Journal of Clinical & Laboratory Research, Vol. 21, No. 2-4, 06.1992, p. 278-282.

Research output: Contribution to journalArticle

@article{7a9cc1ed962e4458a9a654774300308b,
title = "Cytokine gene transfer in tumor cells as an approach to antitumor therapy",
abstract = "The transfer of cytokine genes into cancer cells, resulting in cytokine release directly at the site of tumor growth, has proven effective in inhibiting tumor growth in the absence of any toxic effect. Some cytokines induce tumor suppression even in T-cell-deficient mice, suggesting their potential therapeutic effect in poorly immunogenic tumors; other cytokines induce memory T cells that protect mice from subsequent tumor injection. The effects of cytokine genes transferred into tumor cells are summarized and implications discussed.",
keywords = "Cytokines, Gene transfer, Tumor immunity",
author = "Colombo, {Mario P.} and Stefano Mattei and Giorgio Parmiani",
year = "1992",
month = "6",
doi = "10.1007/BF02591661",
language = "English",
volume = "21",
pages = "278--282",
journal = "Ricerca in Clinica e in Laboratorio",
issn = "0940-5437",
publisher = "Springer Verlag",
number = "2-4",

}

TY - JOUR

T1 - Cytokine gene transfer in tumor cells as an approach to antitumor therapy

AU - Colombo, Mario P.

AU - Mattei, Stefano

AU - Parmiani, Giorgio

PY - 1992/6

Y1 - 1992/6

N2 - The transfer of cytokine genes into cancer cells, resulting in cytokine release directly at the site of tumor growth, has proven effective in inhibiting tumor growth in the absence of any toxic effect. Some cytokines induce tumor suppression even in T-cell-deficient mice, suggesting their potential therapeutic effect in poorly immunogenic tumors; other cytokines induce memory T cells that protect mice from subsequent tumor injection. The effects of cytokine genes transferred into tumor cells are summarized and implications discussed.

AB - The transfer of cytokine genes into cancer cells, resulting in cytokine release directly at the site of tumor growth, has proven effective in inhibiting tumor growth in the absence of any toxic effect. Some cytokines induce tumor suppression even in T-cell-deficient mice, suggesting their potential therapeutic effect in poorly immunogenic tumors; other cytokines induce memory T cells that protect mice from subsequent tumor injection. The effects of cytokine genes transferred into tumor cells are summarized and implications discussed.

KW - Cytokines

KW - Gene transfer

KW - Tumor immunity

UR - http://www.scopus.com/inward/record.url?scp=0026437246&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026437246&partnerID=8YFLogxK

U2 - 10.1007/BF02591661

DO - 10.1007/BF02591661

M3 - Article

VL - 21

SP - 278

EP - 282

JO - Ricerca in Clinica e in Laboratorio

JF - Ricerca in Clinica e in Laboratorio

SN - 0940-5437

IS - 2-4

ER -