Cytokine gene transfer in tumor cells as an approach to antitumor therapy

Mario P. Colombo, Stefano Mattei, Giorgio Parmiani

Research output: Contribution to journalArticle

Abstract

The transfer of cytokine genes into cancer cells, resulting in cytokine release directly at the site of tumor growth, has proven effective in inhibiting tumor growth in the absence of any toxic effect. Some cytokines induce tumor suppression even in T-cell-deficient mice, suggesting their potential therapeutic effect in poorly immunogenic tumors; other cytokines induce memory T cells that protect mice from subsequent tumor injection. The effects of cytokine genes transferred into tumor cells are summarized and implications discussed.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Volume21
Issue number2-4
DOIs
Publication statusPublished - Jun 1992

Keywords

  • Cytokines
  • Gene transfer
  • Tumor immunity

ASJC Scopus subject areas

  • Clinical Biochemistry

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