Abstract
Killer inhibitory receptors (KIRs) represent a new family of HLA-class I-specific receptors. KIRs are involved in the function of Natural Killer cells and allow these cells to discriminate between normal cells and cells with impaired expression of HLA-class I molecules. KIRs are also expressed by a subset of cytolytic T lymphocytes in which they may exert an inhibitory effect on TCR-mediated function. Here we review recent data indicating that cytokines such as IL-15, may induce the de novo expression of CD94/NKG2A (a KIR which operationally detects the expression of various HLA-class I alleles). The expression of CD94/NKG2A has been documented not only in CD34+ precursors undergoing maturation towards NK cells, but also in mature T cells which respond in vitro to superantigens or allogeneic cells.
| Original language | English |
|---|---|
| Pages (from-to) | 69-72 |
| Number of pages | 4 |
| Journal | European Cytokine Network |
| Volume | 9 |
| Issue number | SUPPL. 3 |
| Publication status | Published - 1998 |
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Keywords
- Cytolytic T lymphocytes
- HLA-class I antigens
- Interleukin-15
- Killer inhibitory receptors
- Natural Killer cells
ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Cytokine-induced expression of killer inhibitory receptors in human T lymphocytes. / Moretta, Lorenzo.
In: European Cytokine Network, Vol. 9, No. SUPPL. 3, 1998, p. 69-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokine-induced expression of killer inhibitory receptors in human T lymphocytes.
AU - Moretta, Lorenzo
PY - 1998
Y1 - 1998
N2 - Killer inhibitory receptors (KIRs) represent a new family of HLA-class I-specific receptors. KIRs are involved in the function of Natural Killer cells and allow these cells to discriminate between normal cells and cells with impaired expression of HLA-class I molecules. KIRs are also expressed by a subset of cytolytic T lymphocytes in which they may exert an inhibitory effect on TCR-mediated function. Here we review recent data indicating that cytokines such as IL-15, may induce the de novo expression of CD94/NKG2A (a KIR which operationally detects the expression of various HLA-class I alleles). The expression of CD94/NKG2A has been documented not only in CD34+ precursors undergoing maturation towards NK cells, but also in mature T cells which respond in vitro to superantigens or allogeneic cells.
AB - Killer inhibitory receptors (KIRs) represent a new family of HLA-class I-specific receptors. KIRs are involved in the function of Natural Killer cells and allow these cells to discriminate between normal cells and cells with impaired expression of HLA-class I molecules. KIRs are also expressed by a subset of cytolytic T lymphocytes in which they may exert an inhibitory effect on TCR-mediated function. Here we review recent data indicating that cytokines such as IL-15, may induce the de novo expression of CD94/NKG2A (a KIR which operationally detects the expression of various HLA-class I alleles). The expression of CD94/NKG2A has been documented not only in CD34+ precursors undergoing maturation towards NK cells, but also in mature T cells which respond in vitro to superantigens or allogeneic cells.
KW - Cytolytic T lymphocytes
KW - HLA-class I antigens
KW - Interleukin-15
KW - Killer inhibitory receptors
KW - Natural Killer cells
UR - http://www.scopus.com/inward/record.url?scp=0031768698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031768698&partnerID=8YFLogxK
M3 - Article
C2 - 9831189
AN - SCOPUS:0031768698
VL - 9
SP - 69
EP - 72
JO - Environmental and Molecular Mutagenesis
JF - Environmental and Molecular Mutagenesis
SN - 0893-6692
IS - SUPPL. 3
ER -