Cytokine-induced killer cells as immunotherapy for solid tumors: Current evidence and perspectives

Lidia Giraudo, Loretta Gammaitoni, Michela Cangemi, Ramona Rotolo, Massimo Aglietta, Dario Sangiolo

Research output: Contribution to journalArticle

Abstract

Cytokine-induced killer (CIK) cells are ex vivo expanded T lymphocytes endowed with potent MHC-independent antitumor activity. CIK cells are emerging as promising therapeutic approach in the field of cancer adoptive immunotherapy, with biologic features favoring their transferability into clinical applications. Aim of this review is to present the biologic characteristic of CIK cells, discussing the main preclinical findings and initial clinical applications in the field of solid tumors.

Original languageEnglish
Pages (from-to)999-1010
Number of pages12
JournalImmunotherapy
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • adoptive immunotherapy
  • cytokine-induced killer cells
  • solid tumors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

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