Abstract
The control of viral infections was previously thought to rely exclusively on the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine-dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.
| Original language | English |
|---|---|
| Pages (from-to) | 388-391 |
| Number of pages | 4 |
| Journal | Current Opinion in Microbiology |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1999 |
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ASJC Scopus subject areas
- Microbiology
- Infectious Diseases
Cite this
Cytokine-induced viral purging - Role in viral pathogenesis. / Guidotti, Luca G.; Chisari, Francis V.
In: Current Opinion in Microbiology, Vol. 2, No. 4, 08.1999, p. 388-391.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokine-induced viral purging - Role in viral pathogenesis
AU - Guidotti, Luca G.
AU - Chisari, Francis V.
PY - 1999/8
Y1 - 1999/8
N2 - The control of viral infections was previously thought to rely exclusively on the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine-dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.
AB - The control of viral infections was previously thought to rely exclusively on the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine-dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033179072&partnerID=8YFLogxK
U2 - 10.1016/S1369-5274(99)80068-X
DO - 10.1016/S1369-5274(99)80068-X
M3 - Article
VL - 2
SP - 388
EP - 391
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
IS - 4
ER -