Cytokine-induced viral purging - Role in viral pathogenesis

Luca G. Guidotti, Francis V. Chisari

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The control of viral infections was previously thought to rely exclusively on the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine-dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.

Original languageEnglish
Pages (from-to)388-391
Number of pages4
JournalCurrent Opinion in Microbiology
Volume2
Issue number4
DOIs
Publication statusPublished - Aug 1999

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Virus Diseases
Cytokines
Viruses
Antiviral Agents
Immune System
Antigens

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Cytokine-induced viral purging - Role in viral pathogenesis. / Guidotti, Luca G.; Chisari, Francis V.

In: Current Opinion in Microbiology, Vol. 2, No. 4, 08.1999, p. 388-391.

Research output: Contribution to journalArticle

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