Cytokine-induced viral purging - Role in viral pathogenesis

Luca G. Guidotti, Francis V. Chisari

Research output: Contribution to journalArticlepeer-review


The control of viral infections was previously thought to rely exclusively on the antigen-specific destruction of infected cells by the immune system; however, recent studies have shown that several viral infections can be primarily controlled by noncytopathic, cytokine-dependent 'curative' mechanisms (i.e. viral purging). The relative sensitivity of viruses to such curative mechanisms depends not only on the virus but also on the capacity of the specific infected cell to produce the appropriate intracellular antiviral factors.

Original languageEnglish
Pages (from-to)388-391
Number of pages4
JournalCurrent Opinion in Microbiology
Issue number4
Publication statusPublished - Aug 1999

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


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