Cytokine modulation of HIV expression

Guido Poli, Anthony S. Fauci

Research output: Contribution to journalArticle

Abstract

Cytokines, the peptide hormones which control the homeostasis of the immune system and also play a fundamental role in inflammatory and immune mediated reactions, have been involved at multiple levels in the pathogenesis of the acquired immune deficiency syndrome (AIDS). Infection with the human immunodeficiency virus (HIV) has been shown to induce production of several cytokines both in vitro and in vivo. Conversely, several cytokines modulate the levels of HIV expression n infected cells of both T lymphocytic and mononuclear phagocytic lineage. Activated mononuclear cells, particularly B cells which are in a state of chronic activation in HIV infected individuals, release HIV-inductive cytokines and thus play a potentially important role in the pathogenesis of HIV infection.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalSeminars in Immunology
Volume5
Issue number3
Publication statusPublished - 1993

Keywords

  • Cytokine
  • HIV
  • Lymphocyte
  • Macrophage
  • NF-κB

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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