Cytokine network in chronic perianal crohn's disease and indeterminate colitis after colectomy

Cesare Ruffolo, Marco Scarpa, Diego Faggian, Giovanna Romanato, Annamaria De Pellegrin, Teresa Filosa, Daniela Prando, Lino Polese, Michele Scopelliti, Fabio Pilon, Elena Ossi, Mauro Frego, Davide Francesco D'Amico, Imerio Angriman

Research output: Contribution to journalArticlepeer-review

Abstract

Antitumor necrosis factor alpha (anti-TNF-α) therapy in perianal Crohn's disease (CD) is widely established but recent studies suggest that the underlying fistula tract and inflammation may persist. Treatment with a monoclonal antibody against interleukin (IL)-12 was reported to induce clinical responses and remissions in patients with active CD. The aim of our study was to analyze the cytokine network (TNF-α, IL-12, IL-1β, and IL-6) in 12 patients with chronic perianal CD and a Crohn's disease activity index (CDAI) score

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalJournal of Gastrointestinal Surgery
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Cytokines
  • Indeterminate colitis
  • Perianal Crohn's disease

ASJC Scopus subject areas

  • Surgery

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