Cytokine pattern in blister fluid and serum of patients with bullous pemphigoid: Relationships with disease intensity

F. Ameglio, L. D'Auria, C. Bonifati, C. Ferraro, A. Mastroianni, B. Giacalone

Research output: Contribution to journalArticle

Abstract

Few and contrasting data are available in the literature concerning the levels of various cytokines in blister fluid (BF) and in the serum of patients affected with bullous pemphigoid (BP). Using commercially available ELISA kits, this study reports the levels of 11 cytokines detected both in BF and sera of 15 BP patients and compares them with those of 15 control subjects' sera. Generally, no significant differences were observed in BP and control sera. In contrast, interleukin (IL) 1β, IL-2, IL-4, IL-5, IL-6, IL- 8, tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) showed increased BF levels as compared with BP sera. Two cytokines, IL-11 and IL-12 did not show significant differences between BP BF and sera, while an opposite behaviour was observed for transforming growth factor β1 (TGF- β1), whose serum levels were higher than the concentrations in BF. Using the number of lesions of the patients as a possible disease intensity marker, significant correlations were found with the BF levels of IL-1β, IL-8, TNF- α and, most closely, IL-5. These data may have pathogenetic relevance and suggest the possibility that these biological modulators may be used as a quantitative marker of disease intensity.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalBritish Journal of Dermatology
Volume138
Issue number4
DOIs
Publication statusPublished - 1998

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Bullous Pemphigoid
Blister
Cytokines
Serum
Interleukin-5
Interleukin-8
Interleukin-1
Tumor Necrosis Factor-alpha
Interleukin-11
Transforming Growth Factors
Interleukin-12
Interleukin-4
Interferons
Interleukin-2
Interleukin-6
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Dermatology

Cite this

Cytokine pattern in blister fluid and serum of patients with bullous pemphigoid : Relationships with disease intensity. / Ameglio, F.; D'Auria, L.; Bonifati, C.; Ferraro, C.; Mastroianni, A.; Giacalone, B.

In: British Journal of Dermatology, Vol. 138, No. 4, 1998, p. 611-614.

Research output: Contribution to journalArticle

Ameglio, F. ; D'Auria, L. ; Bonifati, C. ; Ferraro, C. ; Mastroianni, A. ; Giacalone, B. / Cytokine pattern in blister fluid and serum of patients with bullous pemphigoid : Relationships with disease intensity. In: British Journal of Dermatology. 1998 ; Vol. 138, No. 4. pp. 611-614.
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