Cytokine polymorphisms in the pathophysiology of mood disorders

Mario Clerici, Beatrice Arosio, Emanuela Mundo, Elisabetta Cattaneo, Sara Pozzoli, Bernardo Dell'Osso, Carlo Vergani, Daria Trabattoni, A. Carlo Altamura

Research output: Contribution to journalArticle


Introduction: An increasing amount of data suggests that dysregulation of the immune system, including the cytokine network, is associated with the etiology and pathophysiology of mood disorders. Genes encoding cytokines are highly polymorphic and single nucleotide polymorphisms, associated with increased or reduced cytokine production, have been described. The aim of this study was to define the genetic immunologic scenario associated with major depressive disorder (MDD) and bipolar disorder. Methods: Eighty-four Italian outpatients affected by bipolar disorder type I, bipolar disorder type II, or MDD, and 363 healthy controls were enrolled into the study. We analyzed allele and genotype distribution of -308 (G/A) tumor necrosis factor-α (TNF-α), +874 (T/A) interferon-γ (IFN-γ), -174 (G/C) interleukin (IL)-6, and -1082 (G/A) IL-10 promoter polymorphisms by Polymerase Chain Reaction Sequence Specific Primers technique. Results: We observed different genotype and allele distributions of TNF-α, IFN-γ, and IL-10 polymorphisms in the three groups of patients analyzed. In particular, bipolar II patients were characterized by an absence of adenine (A) high producer allele of TNF-α (P

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalCNS Spectrums
Issue number8
Publication statusPublished - 2009


ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Clerici, M., Arosio, B., Mundo, E., Cattaneo, E., Pozzoli, S., Dell'Osso, B., Vergani, C., Trabattoni, D., & Altamura, A. C. (2009). Cytokine polymorphisms in the pathophysiology of mood disorders. CNS Spectrums, 14(8), 419-425.