Cytokine production and adhesive protein expression by endothelial cells after contact with polyethylene terephthalate

E. Cenni, D. Granchi, G. Ciapetti, E. Verri, D. Cavedagna, S. Gamberini, A. Di Leo, A. Pizzoferrato

Research output: Contribution to journalArticle

Abstract

The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1α (IL-1α), interleukin-6 (IL-6), granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in the supernatant was determined by enzyme immunoassay. The contact with PET determined a significant increase in ELAM-1 expression and insignificant increase in cytokine production, demonstrating that PET had a limited capability to stimulate endothelial cells in a pro-inflammatory sense.

Original languageEnglish
Pages (from-to)2071-2076
Number of pages6
JournalBiomaterials
Volume17
Issue number21
DOIs
Publication statusPublished - Nov 1996

Keywords

  • Adhesive protein
  • Cytokine
  • Endothelial cells
  • Polyethylene terephthalate

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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