Cytokine profiles in drug-naive schizophrenic patients

C. L. Cazzullo; E. Sacchetti; A. Galluzzo; A. Panariello; F. Colombo; A. Zagliani; M. Clerici

doi:10.1016/S0920-9964(00)00046-3

Cytokine profiles in drug-naive schizophrenic patients

C. L. Cazzullo, E. Sacchetti, A. Galluzzo, A. Panariello, F. Colombo, A. Zagliani, M. Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

Original language	English
Pages (from-to)	293-298
Number of pages	6
Journal	Schizophrenia Research
Volume	47
Issue number	2-3
DOIs	https://doi.org/10.1016/S0920-9964(00)00046-3
Publication status	Published - Mar 1 2001

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

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AU - Zagliani, A.

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