Cytokine profiles in drug-naive schizophrenic patients

C. L. Cazzullo, E. Sacchetti, A. Galluzzo, A. Panariello, F. Colombo, A. Zagliani, M. Clerici

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A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalSchizophrenia Research
Issue number2-3
Publication statusPublished - Mar 1 2001

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)


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