Abstract
A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.
Original language | English |
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Pages (from-to) | 293-298 |
Number of pages | 6 |
Journal | Schizophrenia Research |
Volume | 47 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - Mar 1 2001 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
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Cytokine profiles in drug-naive schizophrenic patients. / Cazzullo, C. L.; Sacchetti, E.; Galluzzo, A.; Panariello, A.; Colombo, F.; Zagliani, A.; Clerici, M.
In: Schizophrenia Research, Vol. 47, No. 2-3, 01.03.2001, p. 293-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokine profiles in drug-naive schizophrenic patients
AU - Cazzullo, C. L.
AU - Sacchetti, E.
AU - Galluzzo, A.
AU - Panariello, A.
AU - Colombo, F.
AU - Zagliani, A.
AU - Clerici, M.
PY - 2001/3/1
Y1 - 2001/3/1
N2 - A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.
AB - A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035280976&partnerID=8YFLogxK
U2 - 10.1016/S0920-9964(00)00046-3
DO - 10.1016/S0920-9964(00)00046-3
M3 - Article
C2 - 11278147
AN - SCOPUS:0035280976
VL - 47
SP - 293
EP - 298
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 2-3
ER -