Cytokine profiles in drug-naive schizophrenic patients

C. L. Cazzullo, E. Sacchetti, A. Galluzzo, A. Panariello, F. Colombo, A. Zagliani, M. Clerici

Research output: Contribution to journal › Article

69 Citations (Scopus)

Abstract

A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalSchizophrenia Research
Volume47
Issue number2-3
DOIs
Publication statusPublished - Mar 1 2001

Fingerprint

Cytokines
Pharmaceutical Preparations
Interferons
Interleukin-2
Interleukin-4
Interleukin-10
Immune System
Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Cazzullo, C. L., Sacchetti, E., Galluzzo, A., Panariello, A., Colombo, F., Zagliani, A., & Clerici, M. (2001). Cytokine profiles in drug-naive schizophrenic patients. Schizophrenia Research, 47(2-3), 293-298. https://doi.org/10.1016/S0920-9964(00)00046-3

Cytokine profiles in drug-naive schizophrenic patients. / Cazzullo, C. L.; Sacchetti, E.; Galluzzo, A.; Panariello, A.; Colombo, F.; Zagliani, A.; Clerici, M.

In: Schizophrenia Research, Vol. 47, No. 2-3, 01.03.2001, p. 293-298.

Research output: Contribution to journal › Article

Cazzullo, CL, Sacchetti, E, Galluzzo, A, Panariello, A, Colombo, F, Zagliani, A & Clerici, M 2001, 'Cytokine profiles in drug-naive schizophrenic patients', Schizophrenia Research, vol. 47, no. 2-3, pp. 293-298. https://doi.org/10.1016/S0920-9964(00)00046-3
Cazzullo CL, Sacchetti E, Galluzzo A, Panariello A, Colombo F, Zagliani A et al. Cytokine profiles in drug-naive schizophrenic patients. Schizophrenia Research. 2001 Mar 1;47(2-3):293-298. https://doi.org/10.1016/S0920-9964(00)00046-3
Cazzullo, C. L. ; Sacchetti, E. ; Galluzzo, A. ; Panariello, A. ; Colombo, F. ; Zagliani, A. ; Clerici, M. / Cytokine profiles in drug-naive schizophrenic patients. In: Schizophrenia Research. 2001 ; Vol. 47, No. 2-3. pp. 293-298.
@article{878c6f2cfccf4e8cafa471096d0aece3,
title = "Cytokine profiles in drug-naive schizophrenic patients",
abstract = "A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.",
author = "Cazzullo, {C. L.} and E. Sacchetti and A. Galluzzo and A. Panariello and F. Colombo and A. Zagliani and M. Clerici",
year = "2001",
month = "3",
day = "1",
doi = "10.1016/S0920-9964(00)00046-3",
language = "English",
volume = "47",
pages = "293--298",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier B.V.",
number = "2-3",

}

TY - JOUR

T1 - Cytokine profiles in drug-naive schizophrenic patients

AU - Cazzullo, C. L.

AU - Sacchetti, E.

AU - Galluzzo, A.

AU - Panariello, A.

AU - Colombo, F.

AU - Zagliani, A.

AU - Clerici, M.

PY - 2001/3/1

Y1 - 2001/3/1

N2 - A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

AB - A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

UR - http://www.scopus.com/inward/record.url?scp=0035280976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035280976&partnerID=8YFLogxK

U2 - 10.1016/S0920-9964(00)00046-3

DO - 10.1016/S0920-9964(00)00046-3

M3 - Article

C2 - 11278147

AN - SCOPUS:0035280976

VL - 47

SP - 293

EP - 298

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -

Access to Document