Cytokine profiles in drug-naive schizophrenic patients

C. L. Cazzullo; E. Sacchetti; A. Galluzzo; A. Panariello; F. Colombo; A. Zagliani; M. Clerici

doi:10.1016/S0920-9964(00)00046-3

Cytokine profiles in drug-naive schizophrenic patients

C. L. Cazzullo, E. Sacchetti, A. Galluzzo, A. Panariello, F. Colombo, A. Zagliani, M. Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

Original language	English
Pages (from-to)	293-298
Number of pages	6
Journal	Schizophrenia Research
Volume	47
Issue number	2-3
DOIs	https://doi.org/10.1016/S0920-9964(00)00046-3
Publication status	Published - Mar 1 2001

ASJC Scopus subject areas

Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology
Psychology(all)

Access to Document

10.1016/S0920-9964(00)00046-3

Cite this

@article{878c6f2cfccf4e8cafa471096d0aece3,

title = "Cytokine profiles in drug-naive schizophrenic patients",

abstract = "A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.",

author = "Cazzullo, {C. L.} and E. Sacchetti and A. Galluzzo and A. Panariello and F. Colombo and A. Zagliani and M. Clerici",

year = "2001",

month = mar,

day = "1",

doi = "10.1016/S0920-9964(00)00046-3",

language = "English",

volume = "47",

pages = "293--298",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - Cytokine profiles in drug-naive schizophrenic patients

AU - Cazzullo, C. L.

AU - Sacchetti, E.

AU - Galluzzo, A.

AU - Panariello, A.

AU - Colombo, F.

AU - Zagliani, A.

AU - Clerici, M.

PY - 2001/3/1

Y1 - 2001/3/1

N2 - A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

AB - A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-γ] in drug-free (n = 26) and drug-naive (n = 7) schizophrenic patients and in healthy controls (n = 33). Production of IL-2 and INF-γ was significantly higher (respectively P = 0.021 and P = 0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.

UR - http://www.scopus.com/inward/record.url?scp=0035280976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035280976&partnerID=8YFLogxK

U2 - 10.1016/S0920-9964(00)00046-3

DO - 10.1016/S0920-9964(00)00046-3

M3 - Article

C2 - 11278147

AN - SCOPUS:0035280976

VL - 47

SP - 293

EP - 298

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 2-3

ER -

Cytokine profiles in drug-naive schizophrenic patients

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this