Cytokine release and adhesion molecule expression by stimulated human bronchial epithelial cells are downregulated by salmeterol

F. Sabatini, M. Silvestri, R. Sale, L. Serpero, P. Di Blasi, Giovanni A. Rossi

Research output: Contribution to journalArticle

Abstract

β2-adrenoreceptor agonists are able to modulate various aspects of airway cell functions involved in the inflammatory and repair processes characterizing a variety of respiratory disorders. Human bronchial epithelial cells (HBECs), which can act as immune effector cells and express β2-adrenoreceptors, were used to test the effects of different concentrations (0.1-100.0 nM) of salmeterol (Salm) on adhesion molecule expression and chemokine/cytokine release. HBECs, freshly isolated from resected bronchi at the time of surgery in ex-smokers with lung cancer, constitutively expressed over 3 times more ICAM-1 than VCAM-1 (P0.05). Dose-response curves showed that Salm, at concentration >1.0 nM, was effective in inhibiting adhesion molecule expression and cytokine release by HBECs (P0.05), but higher for RANTES (88.4 ± 4.4%), as compared to IL-8 (21.8 ± 7.0%) or GM-CSF (30.1 ± 6.6%; P

Original languageEnglish
Pages (from-to)1052-1060
Number of pages9
JournalRespiratory Medicine
Volume97
Issue number9
DOIs
Publication statusPublished - Sep 1 2003

Keywords

  • β-agonists
  • Adhesion molecules
  • Asthma
  • Cytokine release
  • Epithelial cells

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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