Cytokine secretion in children with acute Mycoplasma pneumoniae infection and wheeze

Susanna Esposito, Roberta Droghetti, Samantha Bosis, Laura Claut, Paola Marchisio, Nicola Principi

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate cytokine secretion in children with acute Mycoplasma pneumoniae infection and wheeze. We studied 25 patients aged 2-14 years with an acute episode of wheezing (15 with acute M. pneumoniae infection) and 16 healthy controls of similar gender and age (8 with laboratory evidence of asymptomatic acute M. pneumoniae infection). Serum interleukin (IL)-2, interferon (IFN)-γ, IL-4, and IL-5 concentrations were measured in samples obtained at enrollment, using enzyme-linked immunosorbent assay kits. In the presence of wheezing, IL-5 concentrations were significantly higher in subjects with acute M. pneumoniae infection (33.415±22.138 pg/mL) than in those without such infection (2.320±1.846 pg/mL, P

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalPediatric Pulmonology
Volume34
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Asthma
  • Children
  • Cytokines
  • Mycoplasma pneumoniae
  • Wheezing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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