Cytokines and adhesion molecules in mesothelial cell pathophysiology

Research output: Contribution to journalArticle

Abstract

The mesothelium is a simple squamous epithelium of mesodermic origin lining peritoneal, pleural and pericardial cavities. The mesothelial lining provides a selective barrier for molecules and cells trafficking between the blood and serous cavities. Serous cavities can be involved by several pathological conditions such as infectious, immune and neoplastic processes that are frequently associated with the formation of effusions and leukocyte recruitment. Mesothelial cells are both a source and a target of proinflammatory mediators, chemokines and growth factors. They actively participate in the regulation of immunity, inflammation, and healing, by expressing in a regulated way cytokines and adhesion molecules.

Original languageEnglish
Pages (from-to)271-283
Number of pages13
JournalSepsis
Volume3
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • Adhesion molecules
  • Chemokines
  • Cytokines
  • Inflammation
  • Mesothelium

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Microbiology (medical)

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