Cytokines and Evolution: In Vitro Effects of IL-1α, IL-1β, TNF-α and TNF-β on an Ancestral Type of Stress Response

E. Ottaviani, E. Caselgrandi, C. Franceschi

Research output: Contribution to journalArticle

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Abstract

Invertebrate hemocytes are immune-neuroendocrine cells which contain a variety of cytokines [Ottaviani et al. (1993) Biochem. Biophys. Res. Commun. 195, 984-988] and release biogenic amines when added to corticotropin-releasing factor (CRF), a phenomenon we have described as an evolutionary proto-type stress response [Ottaviani et al. (1991) Proc. R. Soc. Lond. B 245, 215-218]. Here we show in two molluscs, Planorbarius corneus and Viviparus ater, that this response is significantly reduced when hemocytes are pre-incubated with IL-1α, IL-1β, TNF-α and TNF-β before the addition of CRF. These results confirm and extend the hypothesis that a deep evolutionary relationship exists between cytokines and stress response. Moreover, these data offer an evolutionary basis for understanding the promiscuity of cytokine receptors.

Original languageEnglish
Pages (from-to)288-292
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume207
Issue number1
DOIs
Publication statusPublished - Feb 6 1995

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Hemocytes
Corticotropin-Releasing Hormone
Interleukin-1
Molluscs
Cytokines
Neuroendocrine Cells
Cytokine Receptors
Biogenic Amines
Mollusca
Invertebrates
In Vitro Techniques

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biophysics
  • Biochemistry

Cite this

Cytokines and Evolution : In Vitro Effects of IL-1α, IL-1β, TNF-α and TNF-β on an Ancestral Type of Stress Response. / Ottaviani, E.; Caselgrandi, E.; Franceschi, C.

In: Biochemical and Biophysical Research Communications, Vol. 207, No. 1, 06.02.1995, p. 288-292.

Research output: Contribution to journalArticle

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