Abstract
Invertebrate hemocytes are immune-neuroendocrine cells which contain a variety of cytokines [Ottaviani et al. (1993) Biochem. Biophys. Res. Commun. 195, 984-988] and release biogenic amines when added to corticotropin-releasing factor (CRF), a phenomenon we have described as an evolutionary proto-type stress response [Ottaviani et al. (1991) Proc. R. Soc. Lond. B 245, 215-218]. Here we show in two molluscs, Planorbarius corneus and Viviparus ater, that this response is significantly reduced when hemocytes are pre-incubated with IL-1α, IL-1β, TNF-α and TNF-β before the addition of CRF. These results confirm and extend the hypothesis that a deep evolutionary relationship exists between cytokines and stress response. Moreover, these data offer an evolutionary basis for understanding the promiscuity of cytokine receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 288-292 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 207 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 6 1995 |
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
- Biophysics
- Biochemistry
Cite this
Cytokines and Evolution : In Vitro Effects of IL-1α, IL-1β, TNF-α and TNF-β on an Ancestral Type of Stress Response. / Ottaviani, E.; Caselgrandi, E.; Franceschi, C.
In: Biochemical and Biophysical Research Communications, Vol. 207, No. 1, 06.02.1995, p. 288-292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokines and Evolution
T2 - In Vitro Effects of IL-1α, IL-1β, TNF-α and TNF-β on an Ancestral Type of Stress Response
AU - Ottaviani, E.
AU - Caselgrandi, E.
AU - Franceschi, C.
PY - 1995/2/6
Y1 - 1995/2/6
N2 - Invertebrate hemocytes are immune-neuroendocrine cells which contain a variety of cytokines [Ottaviani et al. (1993) Biochem. Biophys. Res. Commun. 195, 984-988] and release biogenic amines when added to corticotropin-releasing factor (CRF), a phenomenon we have described as an evolutionary proto-type stress response [Ottaviani et al. (1991) Proc. R. Soc. Lond. B 245, 215-218]. Here we show in two molluscs, Planorbarius corneus and Viviparus ater, that this response is significantly reduced when hemocytes are pre-incubated with IL-1α, IL-1β, TNF-α and TNF-β before the addition of CRF. These results confirm and extend the hypothesis that a deep evolutionary relationship exists between cytokines and stress response. Moreover, these data offer an evolutionary basis for understanding the promiscuity of cytokine receptors.
AB - Invertebrate hemocytes are immune-neuroendocrine cells which contain a variety of cytokines [Ottaviani et al. (1993) Biochem. Biophys. Res. Commun. 195, 984-988] and release biogenic amines when added to corticotropin-releasing factor (CRF), a phenomenon we have described as an evolutionary proto-type stress response [Ottaviani et al. (1991) Proc. R. Soc. Lond. B 245, 215-218]. Here we show in two molluscs, Planorbarius corneus and Viviparus ater, that this response is significantly reduced when hemocytes are pre-incubated with IL-1α, IL-1β, TNF-α and TNF-β before the addition of CRF. These results confirm and extend the hypothesis that a deep evolutionary relationship exists between cytokines and stress response. Moreover, these data offer an evolutionary basis for understanding the promiscuity of cytokine receptors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028947776&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1995.1185
DO - 10.1006/bbrc.1995.1185
M3 - Article
C2 - 7857278
AN - SCOPUS:0028947776
VL - 207
SP - 288
EP - 292
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -