Cytokines and microRNA in pediatric B-acute lymphoblastic leukemia

Claudia Cocco, Irma Airoldi

Research output: Contribution to journalArticlepeer-review

Abstract

B-acute lymphoblastic leukemia (ALL) is the most common hematologic tumor of pediatric age. Although patient survival has been improved, some cases still relapse and need alternative therapies. In this context, the role of microRNA in cancer is actually matter of investigation due to their regulatory function implicated in human tumorigenesis since the main target mRNA transcripts are involved in proliferation, apoptosis and differentiation. On the other hand, cytokines are actually used as adjuvants in B-ALL therapy, and recent studies reported that they may also function by acting directly against leukemic cells. Here we review the current knowledge about the role of miRNA and cytokines in B-ALL, highlighting the link between cytokine activity and miRNA expression. The translational relevance of these issues will be also discussed.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume22
Issue number3
DOIs
Publication statusPublished - Jun 2011

Keywords

  • Cytokines
  • Microrna
  • Pediatric B-ALL

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Cytokines and microRNA in pediatric B-acute lymphoblastic leukemia'. Together they form a unique fingerprint.

Cite this