Cytokines and osteolysis around total hip prostheses

S. Stea, M. Visentin, D. Granchi, G. Ciapetti, M. E. Donati, A. Sudanese, C. Zanotti, A. Toni

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The aim of this work is to assess the correlation between the osteolysis around the prosthesis and the presence of cytokines favouring inflammation in the tissues at the interface between loosened prosthesis and bone. In this study, twenty-nine patients that underwent revision surgery were examined. Bioptic samples were collected at the interface between bone and implant both at the stem and socket level. Semiquantitative immunohistochemistry was performed to detect interleukin 1 alpha, interleukin 1 beta, interleakin 6 and tumour necrosis factor, cytokines that directly cause bone resorption and indirectly induce synthesis of other bone resorbing cytokines. Wear particles were identified and quantified by light microscopy. Radiographic evidence for osteolysis was scored by the Engh and Bobyn score. In tissues collected at the interface, the percentage of cells positive to IL1, IL6 and particularly to TNF increased in relation to the tissues collected at the interface with stable components. The cells occurring in the new capsule do not secrete cytokines in quantities that can be related to severity of wear. Cemented prostheses showed higher incidence of severe osteolysis, and higher levels of cytokines. It can be concluded that TNF, and to a lesser extent ILl and IL6, are positively related to the severity of osteolysis around the prosthesis and therefore a pharmacological treatment can be hypothesized with anti-inflammatory or anti-cytokine drugs in order to limit or to avoid prosthesis loosening. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)1575-1579
Number of pages5
JournalCytokine
Volume12
Issue number10
DOIs
Publication statusPublished - 2000

Fingerprint

Hip prostheses
Hip Prosthesis
Osteolysis
Cytokines
Prostheses and Implants
Bone
Tissue
Interleukin-6
Wear of materials
Prosthesis Failure
Bone and Bones
Interleukin-1alpha
Bone Resorption
Prosthetics
Interleukin-1beta
Reoperation
Surgery
Optical microscopy
Capsules
Microscopy

Keywords

  • Cytokine
  • Hip joint
  • Loosening
  • Osteolysis
  • Prosthesis

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Stea, S., Visentin, M., Granchi, D., Ciapetti, G., Donati, M. E., Sudanese, A., ... Toni, A. (2000). Cytokines and osteolysis around total hip prostheses. Cytokine, 12(10), 1575-1579. https://doi.org/10.1006/cyto.2000.0753

Cytokines and osteolysis around total hip prostheses. / Stea, S.; Visentin, M.; Granchi, D.; Ciapetti, G.; Donati, M. E.; Sudanese, A.; Zanotti, C.; Toni, A.

In: Cytokine, Vol. 12, No. 10, 2000, p. 1575-1579.

Research output: Contribution to journalArticle

Stea, S, Visentin, M, Granchi, D, Ciapetti, G, Donati, ME, Sudanese, A, Zanotti, C & Toni, A 2000, 'Cytokines and osteolysis around total hip prostheses', Cytokine, vol. 12, no. 10, pp. 1575-1579. https://doi.org/10.1006/cyto.2000.0753
Stea, S. ; Visentin, M. ; Granchi, D. ; Ciapetti, G. ; Donati, M. E. ; Sudanese, A. ; Zanotti, C. ; Toni, A. / Cytokines and osteolysis around total hip prostheses. In: Cytokine. 2000 ; Vol. 12, No. 10. pp. 1575-1579.
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