Cytokines and VEGF induction in orthodontic movement in animal models

M. Di Domenico, F. D'Apuzzo, A. Feola, L. Cito, A. Monsurrò, G. M. Pierantoni, L. Berrino, A. De Rosa, A. Polimeni, L. Perillo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Orthodontics is a branch of dentistry that aims at the resolution of dental malocclusions. The specialist carries out the treatment using intraoral or extraoral orthodontic appliances that require forces of a given load level to obtain a tooth movement in a certain direction in dental arches. Orthodontic tooth movement is dependent on efficient remodeling of periodontal ligament and alveolar bone, correlated with several biological and mechanical responses of the tissues surrounding the teeth. A periodontal ligament placed under pressure will result in bone resorption whereas a periodontal ligament under tension results in bone formation. In the primary stage of the application of orthodontic forces, an acute inflammation occurs in periodontium. Several proinflammatory cytokines are produced by immune-competent cells migrating by means of dilated capillaries. In this paper we summarize, also through the utilization of animal models, the role of some of these molecules, namely, interleukin-1β and vascular endothelial growth factor, that are some proliferation markers of osteoclasts and osteoblasts, and the macrophage colony stimulating factor.

Original languageEnglish
Article number201689
JournalJournal of Biomedicine and Biotechnology
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Periodontal Ligament
Orthodontics
Vascular Endothelial Growth Factor A
Tooth Movement Techniques
Animal Models
Cytokines
Tooth
Orthodontic Appliances
Dental Arch
Periodontium
Macrophage Colony-Stimulating Factor
Malocclusion
Osteoclasts
Bone Resorption
Dentistry
Osteoblasts
Interleukin-1
Osteogenesis
Inflammation
Pressure

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Genetics
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

Di Domenico, M., D'Apuzzo, F., Feola, A., Cito, L., Monsurrò, A., Pierantoni, G. M., ... Perillo, L. (2012). Cytokines and VEGF induction in orthodontic movement in animal models. Journal of Biomedicine and Biotechnology, 2012, [201689]. https://doi.org/10.1155/2012/201689

Cytokines and VEGF induction in orthodontic movement in animal models. / Di Domenico, M.; D'Apuzzo, F.; Feola, A.; Cito, L.; Monsurrò, A.; Pierantoni, G. M.; Berrino, L.; De Rosa, A.; Polimeni, A.; Perillo, L.

In: Journal of Biomedicine and Biotechnology, Vol. 2012, 201689, 2012.

Research output: Contribution to journalArticle

Di Domenico, M, D'Apuzzo, F, Feola, A, Cito, L, Monsurrò, A, Pierantoni, GM, Berrino, L, De Rosa, A, Polimeni, A & Perillo, L 2012, 'Cytokines and VEGF induction in orthodontic movement in animal models', Journal of Biomedicine and Biotechnology, vol. 2012, 201689. https://doi.org/10.1155/2012/201689
Di Domenico M, D'Apuzzo F, Feola A, Cito L, Monsurrò A, Pierantoni GM et al. Cytokines and VEGF induction in orthodontic movement in animal models. Journal of Biomedicine and Biotechnology. 2012;2012. 201689. https://doi.org/10.1155/2012/201689
Di Domenico, M. ; D'Apuzzo, F. ; Feola, A. ; Cito, L. ; Monsurrò, A. ; Pierantoni, G. M. ; Berrino, L. ; De Rosa, A. ; Polimeni, A. ; Perillo, L. / Cytokines and VEGF induction in orthodontic movement in animal models. In: Journal of Biomedicine and Biotechnology. 2012 ; Vol. 2012.
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