Cytokines in acute myocardial infarction: Selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist

Roberto Latini, Marina Bianchi, Ernesto Correale, Charles A. Dinarello, Giamila Fantuzzi, Claudio Fresco, Aldo P. Maggioni, Manuela Mengozzi, Salvatore Romano, Leland Shapiro, Marina Sironi, Gianni Tognoni, Roberto Turato, Pietro Ghezzi

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokines play a pathogenetic role in a variety of infective and inflammatory diseases. In the present study, we had two objectives: (a) to define the kinetics of tumor necrosis factor (TNF) in plasma after acute myocardial infarction (AMI) in patients treated with early thrombolysis, and (b) to measure other cytokines, interleukin-1 (IL-1) and TNF receptor antagonists, in plasma. TNF-α, but not IL-1β or IL-8, was present in plasma of 6 of 7 patients with severe AMI (Killip class 3 or 4). No TNF (

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume23
Issue number1
Publication statusPublished - 1994

Keywords

  • Cytokines
  • Inter-leukin-1
  • Myocardial infarction
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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