Cytokines in the pathogenesis of multiple sclerosis.

P. B. Carrieri, A. Maiorino, V. Provitera, E. Soscia, O. Perrella

Research output: Contribution to journalArticlepeer-review


The authors evaluate the involvement of various cytokines (interleukin-1, interleukin-2, interleukin-4, interleukin-6, tumor necrosis factor alpha and gamma-interferon) in the pathogenesis of multiple sclerosis. The cytokines might participate in nervous tissue damage by promoting demyelination and oligodendrocyte injury or by enhancing local immune response. In addition, several authors reported increased levels of some cytokines in serum and cerebrospinal fluid of patients with multiple sclerosis. These findings suggest that cytokines can play a significant role in the immunopathogenesis of the disease.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalActa Neurologica
Issue number4-6
Publication statusPublished - Aug 1992

ASJC Scopus subject areas

  • Clinical Neurology


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