Cytokines production in chronic schizophrenia patients with or without paranoid behaviour

Carlo L. Cazzullo, Silvio Scarone, Barbara Grassi, Chiara Vismara, Daria Trabattoni, Massimo Clerici, Mario Clerici

Research output: Contribution to journalArticle

Abstract

1. Several immunological abnormalities have been found in schizophrenia but their significance still remains largely unknown. In this study the authors analyzed mitogen-stimulated interleukin (IL)-2, Interferon gamma (IFN)-γ and IL-10 (type 2 cytokine) production in a sample of 37 chronic schizophrenic patients as compared with a sample of 40 age and sex-matched controls with the aim to evaluate whether patients belonging to different diagnostic subtypes (i..e. paranoid patients vs non paranoid patients) could be immunologically different from each other. 2. The findings indicate that paranoid patients produce less IL-10 than the others and thus, from an immunological viewpoint, they are more similar to healthy controls. 3. Furthermore, neuroleptic medications were observed to differently affect IL-2 production; this preliminary finding might stimulate further studies aiming to get a link between different drug profile of action both in terms of clinical and receptorial profile and different immunological effects.

Original languageEnglish
Pages (from-to)947-957
Number of pages11
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume22
Issue number6
Publication statusPublished - Aug 1998

Keywords

  • Cell mediated immunity
  • Cytokine production
  • Interleukin-10
  • Interleukin-2
  • Neuroleptic drugs
  • Paranoia
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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  • Cite this

    Cazzullo, C. L., Scarone, S., Grassi, B., Vismara, C., Trabattoni, D., Clerici, M., & Clerici, M. (1998). Cytokines production in chronic schizophrenia patients with or without paranoid behaviour. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 22(6), 947-957.