Cytokines that regulate autoimmune responses

Marika Falcone, Nora Sarvetnick

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Autoimmune responses are controlled by complex regulatory circuits. Previous work has revealed that factors controlling autoimmunity can act both as potentiating and inhibitory agents, depending upon the site and timing of exposure. Recent advances in this complex field have at least partially uncovered the mechanism whereby these regulatory molecules participate in autoimmune processes. IL-12 production in the absence of infection may predispose to autoimmunity IL-4 and transforming growth factor β may suppress autoreactive T cells. Proinflammatory cytokines may ameliorate autoimmunity, dependent on the timing and level of production. In many cases, cytokines may act via antigen-presenting cells.

Original languageEnglish
Pages (from-to)670-676
Number of pages7
JournalCurrent Opinion in Immunology
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 1 1999

Fingerprint

Autoimmunity
Cytokines
Transforming Growth Factors
Antigen-Presenting Cells
Interleukin-12
Interleukin-4
T-Lymphocytes
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cytokines that regulate autoimmune responses. / Falcone, Marika; Sarvetnick, Nora.

In: Current Opinion in Immunology, Vol. 11, No. 6, 01.12.1999, p. 670-676.

Research output: Contribution to journalArticle

Falcone, Marika ; Sarvetnick, Nora. / Cytokines that regulate autoimmune responses. In: Current Opinion in Immunology. 1999 ; Vol. 11, No. 6. pp. 670-676.
@article{ff0d979fcc4d40c684d619829d34da20,
title = "Cytokines that regulate autoimmune responses",
abstract = "Autoimmune responses are controlled by complex regulatory circuits. Previous work has revealed that factors controlling autoimmunity can act both as potentiating and inhibitory agents, depending upon the site and timing of exposure. Recent advances in this complex field have at least partially uncovered the mechanism whereby these regulatory molecules participate in autoimmune processes. IL-12 production in the absence of infection may predispose to autoimmunity IL-4 and transforming growth factor β may suppress autoreactive T cells. Proinflammatory cytokines may ameliorate autoimmunity, dependent on the timing and level of production. In many cases, cytokines may act via antigen-presenting cells.",
author = "Marika Falcone and Nora Sarvetnick",
year = "1999",
month = "12",
day = "1",
doi = "10.1016/S0952-7915(99)00035-7",
language = "English",
volume = "11",
pages = "670--676",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Cytokines that regulate autoimmune responses

AU - Falcone, Marika

AU - Sarvetnick, Nora

PY - 1999/12/1

Y1 - 1999/12/1

N2 - Autoimmune responses are controlled by complex regulatory circuits. Previous work has revealed that factors controlling autoimmunity can act both as potentiating and inhibitory agents, depending upon the site and timing of exposure. Recent advances in this complex field have at least partially uncovered the mechanism whereby these regulatory molecules participate in autoimmune processes. IL-12 production in the absence of infection may predispose to autoimmunity IL-4 and transforming growth factor β may suppress autoreactive T cells. Proinflammatory cytokines may ameliorate autoimmunity, dependent on the timing and level of production. In many cases, cytokines may act via antigen-presenting cells.

AB - Autoimmune responses are controlled by complex regulatory circuits. Previous work has revealed that factors controlling autoimmunity can act both as potentiating and inhibitory agents, depending upon the site and timing of exposure. Recent advances in this complex field have at least partially uncovered the mechanism whereby these regulatory molecules participate in autoimmune processes. IL-12 production in the absence of infection may predispose to autoimmunity IL-4 and transforming growth factor β may suppress autoreactive T cells. Proinflammatory cytokines may ameliorate autoimmunity, dependent on the timing and level of production. In many cases, cytokines may act via antigen-presenting cells.

UR - http://www.scopus.com/inward/record.url?scp=0032754990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032754990&partnerID=8YFLogxK

U2 - 10.1016/S0952-7915(99)00035-7

DO - 10.1016/S0952-7915(99)00035-7

M3 - Article

C2 - 10631553

AN - SCOPUS:0032754990

VL - 11

SP - 670

EP - 676

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 6

ER -