Cytokinetic studies in acute leukemia during early induction therapy

E. Traversi, A. Riccardi, C. Montecucco, G. Mazzini, P. Giordano

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Abstract

The proliferative activity of bone marrow blasts was determined in 19 patients with acute leukemia during early induction therapy using in vitro tritiated thymidine (3H-TdR) cytoautoradiography and propidium iodide DNA flow cytofluorometry. Following 1-3 courses of treatment, the aliquot of bone marrow blasts in 9 patients, who later achieved remission or marrow aplasia, was reduced to a greater extent than that of the remaining 10 patients who failed to respond. In the first group of patients, the 3H-TdR labelling index was increased by 259-653% over the pretreatment value, whereas it was lower than 104% of the pretreatment value in all but one unresponsive patient. Leukemic blast recruitment is conceivable. It might have facilitated remission by increasing the effectiveness of the antileukemic agents administered later.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalTumori
Volume71
Issue number1
Publication statusPublished - 1985

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Secondary Prevention
Leukemia
Bone Marrow
Propidium
Thymidine
Flow Cytometry
DNA
Therapeutics

ASJC Scopus subject areas

  • Cancer Research

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Cytokinetic studies in acute leukemia during early induction therapy. / Traversi, E.; Riccardi, A.; Montecucco, C.; Mazzini, G.; Giordano, P.

In: Tumori, Vol. 71, No. 1, 1985, p. 69-74.

Research output: Contribution to journalArticle

Traversi, E, Riccardi, A, Montecucco, C, Mazzini, G & Giordano, P 1985, 'Cytokinetic studies in acute leukemia during early induction therapy', Tumori, vol. 71, no. 1, pp. 69-74.
Traversi, E. ; Riccardi, A. ; Montecucco, C. ; Mazzini, G. ; Giordano, P. / Cytokinetic studies in acute leukemia during early induction therapy. In: Tumori. 1985 ; Vol. 71, No. 1. pp. 69-74.
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