Abstract
The proliferative activity of bone marrow blasts was determined in 19 patients with acute leukemia during early induction therapy using in vitro tritiated thymidine (3H-TdR) cytoautoradiography and propidium iodide DNA flow cytofluorometry. Following 1-3 courses of treatment, the aliquot of bone marrow blasts in 9 patients, who later achieved remission or marrow aplasia, was reduced to a greater extent than that of the remaining 10 patients who failed to respond. In the first group of patients, the 3H-TdR labelling index was increased by 259-653% over the pretreatment value, whereas it was lower than 104% of the pretreatment value in all but one unresponsive patient. Leukemic blast recruitment is conceivable. It might have facilitated remission by increasing the effectiveness of the antileukemic agents administered later.
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Tumori |
| Volume | 71 |
| Issue number | 1 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Cancer Research
Cite this
Cytokinetic studies in acute leukemia during early induction therapy. / Traversi, E.; Riccardi, A.; Montecucco, C.; Mazzini, G.; Giordano, P.
In: Tumori, Vol. 71, No. 1, 1985, p. 69-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytokinetic studies in acute leukemia during early induction therapy
AU - Traversi, E.
AU - Riccardi, A.
AU - Montecucco, C.
AU - Mazzini, G.
AU - Giordano, P.
PY - 1985
Y1 - 1985
N2 - The proliferative activity of bone marrow blasts was determined in 19 patients with acute leukemia during early induction therapy using in vitro tritiated thymidine (3H-TdR) cytoautoradiography and propidium iodide DNA flow cytofluorometry. Following 1-3 courses of treatment, the aliquot of bone marrow blasts in 9 patients, who later achieved remission or marrow aplasia, was reduced to a greater extent than that of the remaining 10 patients who failed to respond. In the first group of patients, the 3H-TdR labelling index was increased by 259-653% over the pretreatment value, whereas it was lower than 104% of the pretreatment value in all but one unresponsive patient. Leukemic blast recruitment is conceivable. It might have facilitated remission by increasing the effectiveness of the antileukemic agents administered later.
AB - The proliferative activity of bone marrow blasts was determined in 19 patients with acute leukemia during early induction therapy using in vitro tritiated thymidine (3H-TdR) cytoautoradiography and propidium iodide DNA flow cytofluorometry. Following 1-3 courses of treatment, the aliquot of bone marrow blasts in 9 patients, who later achieved remission or marrow aplasia, was reduced to a greater extent than that of the remaining 10 patients who failed to respond. In the first group of patients, the 3H-TdR labelling index was increased by 259-653% over the pretreatment value, whereas it was lower than 104% of the pretreatment value in all but one unresponsive patient. Leukemic blast recruitment is conceivable. It might have facilitated remission by increasing the effectiveness of the antileukemic agents administered later.
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M3 - Article
VL - 71
SP - 69
EP - 74
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 1
ER -