Cytologic Diagnosis of Oncocytic Neoplasms of the Thyroid Gland: The Importance of the Clinical Scenario

Patrizia Straccia, Giuseppe Santeusanio, Francesco Pierconti, Chiara Brunelli, Guido Fadda

Research output: Contribution to journalArticle

Abstract

It is a diagnostic challenge to differentiate benign and malignant thyroid neoplasms made up of Hürthle (or oncocytic) cells on cytologic material. They are large, polygonal cells with marked eosinophilic, granular cytoplasm reflective of overly abundant mitochondria. These cells commonly occur in nodular goiters and dominant adenomatous or hyperplastic nodules though they may also be the predominant component of neoplastic lesions. There are significant controversies concerning the optimal management of patients with oncocytic cell carcinoma. This review provides an overview of the most significant studies addressing the distinction between benign and malignant Hürthle cell lesions on cytology and histology.

Original languageEnglish
JournalApplied Immunohistochemistry and Molecular Morphology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Hurthle cells
  • neoplasm
  • oncocytes
  • thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology

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