Cytology, cytochemistry and ultrastructure of glucagon-secreting cells

Cesare Cavallero, Enrico Solcia, Gabriele Vassallo, Carlo Capella, Giuseppe Bussolati

Research output: Contribution to journalArticle


The main morphological methods for the detection of islet A-cells are considered and their selectivity discussed, with special reference to indole methods and to immunohistochemical and electron microscope observations. Immunohistochemical data on A-cells as glucagon-secreting cells and electron microscope observations suggesting heterogeneity of α-granules are reported. There is at present no definitive morphological proof of the existence of gastrointestinal A-cells.

Original languageEnglish
Pages (from-to)542-556
Number of pages15
JournalActa Diabetologica Latina
Issue number1
Publication statusPublished - Jan 1970


  • α-granules
  • A-cell
  • Cytochemistry
  • Cytology
  • Enteroglucagon
  • Glucagon
  • Glucagonsecreting cells
  • Pancreatic islets
  • Ultrastructure

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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