The morphology and function of the endocrine cell types forming the diffuse (neuro)endocrine system, with special reference to its gastroenteropancreatic and pulmonary parts, have been revised in the light of recent developments in ultrastructural and histochemical studies of these cells. The results of parallel histochemical and ultrastructural investigations on endocrine tumours arising in the same tissues have been reported. These results allowed the identification of the cell types, appropriate or inappropriate to the tissue, composing many of such tumours, and the proposal of cytologically and functionally based tumour classifications. Moreover, comparison of these data with clinico-pathologic findings outlined the advantages and limits of cytologic studies for understanding the natural history of neuroendocrine tumours and improving our diagnostic and prognostic criteria.
|Number of pages||28|
|Journal||Fernstrom Foundation Series|
|Publication status||Published - 1984|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)