Abstract
Male infertility may be due to a multiplicity of etiologic factors. In this study we have investigated the presence of cytomegalovirus (CMV) in 150 infertile men (selected after the exclusion of other etiopathogenic factors of infertility) and 80 subjects screened for pre-marriage consult. CMV was found in the sperm of 7/150 patients and 3/80 subjects screened for pre-marriage consult. Moreover, the seminal abnormalities evidenced in infertile men (a significant decrease of nemaspermic concentration and motility, of fructose, a significantly increased pH) were also observed in subjects screened for pre-marriage consult having CMV in the sperm. These abnormalities were related to alterations of cell-mediated immunity (decreased OKT4+, increased OKT8+ with decreased OKT4/OKT8 ratio). Among ten CMV+ subjects, two with idiopathic sterility and three subjects screened for pre-marriage consult showed a negativization of CMV in the sperm, during the observation period (one year), and a decreased anti-CMV titre lower than eight. Contemporary, a normalization of immunologic and seminal parameters was observed.
| Original language | English |
|---|---|
| Pages (from-to) | 440-443 |
| Number of pages | 4 |
| Journal | Annales de Biologie Clinique |
| Volume | 45 |
| Issue number | 4 |
| Publication status | Published - 1987 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Medicine (miscellaneous)
Cite this
Cytomegalovirus and male infertility. / Torino, G.; Bizzarro, A.; Castello, G.; Daponte, A.; Fontana, A.; De Bellis, A.; Paglionico, V. A.
In: Annales de Biologie Clinique, Vol. 45, No. 4, 1987, p. 440-443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytomegalovirus and male infertility.
AU - Torino, G.
AU - Bizzarro, A.
AU - Castello, G.
AU - Daponte, A.
AU - Fontana, A.
AU - De Bellis, A.
AU - Paglionico, V. A.
PY - 1987
Y1 - 1987
N2 - Male infertility may be due to a multiplicity of etiologic factors. In this study we have investigated the presence of cytomegalovirus (CMV) in 150 infertile men (selected after the exclusion of other etiopathogenic factors of infertility) and 80 subjects screened for pre-marriage consult. CMV was found in the sperm of 7/150 patients and 3/80 subjects screened for pre-marriage consult. Moreover, the seminal abnormalities evidenced in infertile men (a significant decrease of nemaspermic concentration and motility, of fructose, a significantly increased pH) were also observed in subjects screened for pre-marriage consult having CMV in the sperm. These abnormalities were related to alterations of cell-mediated immunity (decreased OKT4+, increased OKT8+ with decreased OKT4/OKT8 ratio). Among ten CMV+ subjects, two with idiopathic sterility and three subjects screened for pre-marriage consult showed a negativization of CMV in the sperm, during the observation period (one year), and a decreased anti-CMV titre lower than eight. Contemporary, a normalization of immunologic and seminal parameters was observed.
AB - Male infertility may be due to a multiplicity of etiologic factors. In this study we have investigated the presence of cytomegalovirus (CMV) in 150 infertile men (selected after the exclusion of other etiopathogenic factors of infertility) and 80 subjects screened for pre-marriage consult. CMV was found in the sperm of 7/150 patients and 3/80 subjects screened for pre-marriage consult. Moreover, the seminal abnormalities evidenced in infertile men (a significant decrease of nemaspermic concentration and motility, of fructose, a significantly increased pH) were also observed in subjects screened for pre-marriage consult having CMV in the sperm. These abnormalities were related to alterations of cell-mediated immunity (decreased OKT4+, increased OKT8+ with decreased OKT4/OKT8 ratio). Among ten CMV+ subjects, two with idiopathic sterility and three subjects screened for pre-marriage consult showed a negativization of CMV in the sperm, during the observation period (one year), and a decreased anti-CMV titre lower than eight. Contemporary, a normalization of immunologic and seminal parameters was observed.
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M3 - Article
VL - 45
SP - 440
EP - 443
JO - Annales de Biologie Clinique
JF - Annales de Biologie Clinique
SN - 0003-3898
IS - 4
ER -