Abstract
Neuroblastoma is one of the most frequent solid tumors in childhood, rarely recurrent after five years from diagnosis. Cytomegalovirus (CMV), a major pathogen causing congenital birth defects and severe opportunistic diseases, has been shown to have teratogenic, immunodepressive and oncogenic properties. The case of a girl with stage 4S neuroblastoma diagnosed at three months and relapsed as stage 4 live years later is reported. In both circumstances, active CMV infection was revealed by positive CMV-specific IgM and IgA antibodies, CMV-DNAemia and CMV culture. At three months, the patient presented with subcutaneous nodules, hepatosplenomegaly and increased aminotransferase levels, and the opsoclonus-myoclonus syndrome. Mental retardation developed later on. At 5 years, relapsed neuroblastoma was preceded by a mononucleosis-like syndrome concomitant with active CMV infection and decreased levels of immune cells and natural killer activity. Clinical, virologic, and immunologic findings suggest an immune-mediated pathogenic role for CMV in this tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 200-203 |
| Number of pages | 4 |
| Journal | Medical and Pediatric Oncology |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- cell-mediated immunity
- childhood
- cytomegalovirus
- Kinsbourne's syndrome
- neuroblastoma
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Oncology
- Cancer Research
Cite this
Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4. / Nigro, G.; Schiavetti, A.; Booth, J. C.; Clerico, A.; Dominici, C.; Krzysztofiak, A.; Castello, M.
In: Medical and Pediatric Oncology, Vol. 24, No. 3, 1995, p. 200-203.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4
AU - Nigro, G.
AU - Schiavetti, A.
AU - Booth, J. C.
AU - Clerico, A.
AU - Dominici, C.
AU - Krzysztofiak, A.
AU - Castello, M.
PY - 1995
Y1 - 1995
N2 - Neuroblastoma is one of the most frequent solid tumors in childhood, rarely recurrent after five years from diagnosis. Cytomegalovirus (CMV), a major pathogen causing congenital birth defects and severe opportunistic diseases, has been shown to have teratogenic, immunodepressive and oncogenic properties. The case of a girl with stage 4S neuroblastoma diagnosed at three months and relapsed as stage 4 live years later is reported. In both circumstances, active CMV infection was revealed by positive CMV-specific IgM and IgA antibodies, CMV-DNAemia and CMV culture. At three months, the patient presented with subcutaneous nodules, hepatosplenomegaly and increased aminotransferase levels, and the opsoclonus-myoclonus syndrome. Mental retardation developed later on. At 5 years, relapsed neuroblastoma was preceded by a mononucleosis-like syndrome concomitant with active CMV infection and decreased levels of immune cells and natural killer activity. Clinical, virologic, and immunologic findings suggest an immune-mediated pathogenic role for CMV in this tumor.
AB - Neuroblastoma is one of the most frequent solid tumors in childhood, rarely recurrent after five years from diagnosis. Cytomegalovirus (CMV), a major pathogen causing congenital birth defects and severe opportunistic diseases, has been shown to have teratogenic, immunodepressive and oncogenic properties. The case of a girl with stage 4S neuroblastoma diagnosed at three months and relapsed as stage 4 live years later is reported. In both circumstances, active CMV infection was revealed by positive CMV-specific IgM and IgA antibodies, CMV-DNAemia and CMV culture. At three months, the patient presented with subcutaneous nodules, hepatosplenomegaly and increased aminotransferase levels, and the opsoclonus-myoclonus syndrome. Mental retardation developed later on. At 5 years, relapsed neuroblastoma was preceded by a mononucleosis-like syndrome concomitant with active CMV infection and decreased levels of immune cells and natural killer activity. Clinical, virologic, and immunologic findings suggest an immune-mediated pathogenic role for CMV in this tumor.
KW - cell-mediated immunity
KW - childhood
KW - cytomegalovirus
KW - Kinsbourne's syndrome
KW - neuroblastoma
UR - http://www.scopus.com/inward/record.url?scp=0028881604&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028881604&partnerID=8YFLogxK
U2 - 10.1002/mpo.2950240311
DO - 10.1002/mpo.2950240311
M3 - Article
C2 - 7838043
AN - SCOPUS:0028881604
VL - 24
SP - 200
EP - 203
JO - Pediatric Blood and Cancer
JF - Pediatric Blood and Cancer
SN - 1545-5009
IS - 3
ER -