Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4

G. Nigro, A. Schiavetti, J. C. Booth, A. Clerico, C. Dominici, A. Krzysztofiak, M. Castello

Research output: Contribution to journalArticle

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Abstract

Neuroblastoma is one of the most frequent solid tumors in childhood, rarely recurrent after five years from diagnosis. Cytomegalovirus (CMV), a major pathogen causing congenital birth defects and severe opportunistic diseases, has been shown to have teratogenic, immunodepressive and oncogenic properties. The case of a girl with stage 4S neuroblastoma diagnosed at three months and relapsed as stage 4 live years later is reported. In both circumstances, active CMV infection was revealed by positive CMV-specific IgM and IgA antibodies, CMV-DNAemia and CMV culture. At three months, the patient presented with subcutaneous nodules, hepatosplenomegaly and increased aminotransferase levels, and the opsoclonus-myoclonus syndrome. Mental retardation developed later on. At 5 years, relapsed neuroblastoma was preceded by a mononucleosis-like syndrome concomitant with active CMV infection and decreased levels of immune cells and natural killer activity. Clinical, virologic, and immunologic findings suggest an immune-mediated pathogenic role for CMV in this tumor.

Original languageEnglish
Pages (from-to)200-203
Number of pages4
JournalMedical and Pediatric Oncology
Volume24
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Cytomegalovirus
Neuroblastoma
Cytomegalovirus Infections
Opsoclonus-Myoclonus Syndrome
Transaminases
Intellectual Disability
Natural Killer Cells
Immunoglobulin A
Immunoglobulin M
Neoplasms
Antibodies

Keywords

  • cell-mediated immunity
  • childhood
  • cytomegalovirus
  • Kinsbourne's syndrome
  • neuroblastoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Nigro, G., Schiavetti, A., Booth, J. C., Clerico, A., Dominici, C., Krzysztofiak, A., & Castello, M. (1995). Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4. Medical and Pediatric Oncology, 24(3), 200-203. https://doi.org/10.1002/mpo.2950240311

Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4. / Nigro, G.; Schiavetti, A.; Booth, J. C.; Clerico, A.; Dominici, C.; Krzysztofiak, A.; Castello, M.

In: Medical and Pediatric Oncology, Vol. 24, No. 3, 1995, p. 200-203.

Research output: Contribution to journalArticle

Nigro, G, Schiavetti, A, Booth, JC, Clerico, A, Dominici, C, Krzysztofiak, A & Castello, M 1995, 'Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4', Medical and Pediatric Oncology, vol. 24, no. 3, pp. 200-203. https://doi.org/10.1002/mpo.2950240311
Nigro, G. ; Schiavetti, A. ; Booth, J. C. ; Clerico, A. ; Dominici, C. ; Krzysztofiak, A. ; Castello, M. / Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4. In: Medical and Pediatric Oncology. 1995 ; Vol. 24, No. 3. pp. 200-203.
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