Cytomegalovirus DNAemia in pregnant women

Maria Grazia Revello, Milena Furione, Vanina Rognoni, Alessia Arossa, Giuseppe Gerna

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cytomegalovirus (CMV) transmission from mother to fetus occurs at a much greater rate following primary rather than reactivated infections and CMV dissemination in the mother is considered a key step in the pathogenesis of fetal infection. However, knowledge of CMV DNAemia in CMV-seropositive pregnant women is very limited. Objective: Major objective of this study was to assess the prevalence and diagnostic value of CMV DNAemia in a large population of seropositive pregnant women. Study design: Serologic and DNAemia results obtained from 2211 blood samples of 1371 consecutive pregnant women referred to our Institution for suspected CMV infection in the period 2001-2010 were reviewed. Results: DNAemia was detected in 452/597 (75.7%) women with serologic evidence of primary CMV infection and in 4/774 (0.5%) women without evidence of primary infection. Conclusion: In pregnant women, CMV DNAemia is detected primarily during primary infection. CMV DNAemia determination may be helpful in the diagnosis of primary infection.

Original languageEnglish
Pages (from-to)590-592
Number of pages3
JournalJournal of Clinical Virology
Volume61
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • DNAemia
  • Human cytomegalovirus
  • Non-primary infection
  • Pregnancy
  • Primary infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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