Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case

Anastasios Stathis, Stefano L. Rosa, Ilaria Proserpio, Donata Micello, Claudio Chini, Graziella Pinotti

Research output: Contribution to journalArticle

Abstract

Cytomegalovirus (CMV) is an opportunistic pathogen causing different diseases in immunocompromised patients and leading to death in a high percentage of cases. CMV infection is also relatively frequent among patients with hematological malignancies, especially when treated with immunosuppressive agents. We describe the clinical history of a patient with stage IV diffuse large B-cell lymphoma (DLBCL) treated with eight courses of R-CHOP every two weeks, who presented clinical remission of the disease at the end of therapy. However, two months later he developed neurological symptoms due to cerebellar involvement and a subcutaneous dorsal lymphomatous infiltration. He had a partial response after chemotherapy and brain radiotherapy, but his clinical course was complicated by fever and hypotension. Although the fever resolved with broad-spectrum antibiotics, he presented progressive endocrine failure and died three weeks later. Autopsy confirmed disseminated multi-organ involvement by DLBCL associated with an unexpected CMV infection of the lungs and several endocrine organs including the pituitary gland, pancreatic islets and adrenals, a clinical association not previously reported in the English literature.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalTumori
Volume95
Issue number1
Publication statusPublished - Jan 2009

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Endocrine System
Lymphoma, Large B-Cell, Diffuse
Cytomegalovirus Infections
Fever
Literature
Immunocompromised Host
Hematologic Neoplasms
Pituitary Gland
Immunosuppressive Agents
Cytomegalovirus
Islets of Langerhans
Hypotension
Autopsy
Radiotherapy
History
Anti-Bacterial Agents
Drug Therapy
Lung
Brain
Therapeutics

Keywords

  • Cytomegalovirus
  • Diffuse large b-cell lymphoma
  • Endocrine system
  • Multiendocrine failure

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Stathis, A., Rosa, S. L., Proserpio, I., Micello, D., Chini, C., & Pinotti, G. (2009). Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case. Tumori, 95(1), 119-122.

Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case. / Stathis, Anastasios; Rosa, Stefano L.; Proserpio, Ilaria; Micello, Donata; Chini, Claudio; Pinotti, Graziella.

In: Tumori, Vol. 95, No. 1, 01.2009, p. 119-122.

Research output: Contribution to journalArticle

Stathis, A, Rosa, SL, Proserpio, I, Micello, D, Chini, C & Pinotti, G 2009, 'Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case', Tumori, vol. 95, no. 1, pp. 119-122.
Stathis, Anastasios ; Rosa, Stefano L. ; Proserpio, Ilaria ; Micello, Donata ; Chini, Claudio ; Pinotti, Graziella. / Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case. In: Tumori. 2009 ; Vol. 95, No. 1. pp. 119-122.
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