Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case

Anastasios Stathis, Stefano L. Rosa, Ilaria Proserpio, Donata Micello, Claudio Chini, Graziella Pinotti

Research output: Contribution to journalArticlepeer-review

Abstract

Cytomegalovirus (CMV) is an opportunistic pathogen causing different diseases in immunocompromised patients and leading to death in a high percentage of cases. CMV infection is also relatively frequent among patients with hematological malignancies, especially when treated with immunosuppressive agents. We describe the clinical history of a patient with stage IV diffuse large B-cell lymphoma (DLBCL) treated with eight courses of R-CHOP every two weeks, who presented clinical remission of the disease at the end of therapy. However, two months later he developed neurological symptoms due to cerebellar involvement and a subcutaneous dorsal lymphomatous infiltration. He had a partial response after chemotherapy and brain radiotherapy, but his clinical course was complicated by fever and hypotension. Although the fever resolved with broad-spectrum antibiotics, he presented progressive endocrine failure and died three weeks later. Autopsy confirmed disseminated multi-organ involvement by DLBCL associated with an unexpected CMV infection of the lungs and several endocrine organs including the pituitary gland, pancreatic islets and adrenals, a clinical association not previously reported in the English literature.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalTumori
Volume95
Issue number1
Publication statusPublished - Jan 2009

Keywords

  • Cytomegalovirus
  • Diffuse large b-cell lymphoma
  • Endocrine system
  • Multiendocrine failure

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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