This report deals with the results of a preclinical cytopathological study on Pipotiazine palmitate, a new slow-release phenotiazine. Thirty mice were given the drug i.m., while only the solvent was administered to the control group. Three experimental sets, each employing 10 treated and 10 control mice, were carried out, according to the following dosages: 1/3 of LD50 once (acute experiment); 1/50 of LD50 for 10 days (subacute experiment) and 1/200 of LD50 for 30 days (chronic experiment). Experimental findings suggest evidence of a sedative long-acting neuroleptic action of the drug concerned. No side-effects were noticed. Subcortical (deep) changes (such as reduced cytoplasm, injured cell membrane, reduced chromatine) and cortical (superficial) changes (such as swelling, visible axon, unmodified nucleus) were observed.
|Translated title of the contribution||Cytopathologic investigation of some long acting psychotropic drugs. IV. Pipotiazine palmitate|
|Title of host publication||Morgagni|
|Number of pages||14|
|Publication status||Published - 1976|
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