Cytopathological features of cell suffering and death: Role of plasma membrane and cytoskeleton

W. Malorni, F. Iosi, S. Meschini, S. Paradisi, G. Donelli

Research output: Contribution to journalArticlepeer-review

Abstract

Morphological and ultrastructural modifications related to the cell injury and leading to cell death have been investigated by using different compounds. Data obtained by treating various cultured cells with a quinone (menadione), a polar solvent (NMF) and a bacterial protein toxin (toxin B from Clostridiumdifficile) are here reported Differences seem to exist between such injuries, but changes in plasma membrane structure, called surface blebbing phenomenon, represent a common feature which can be in any case detected. Our results also allow to hypothesize an important role of cytoskeleton in such a process.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalCytotechnology
Volume5
Issue number1 Supplement
DOIs
Publication statusPublished - Feb 1991

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

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