Cytoprotection against neutrophil derived hypochlorous acid: A potential mechanism for the therapeutic action of 5-aminosalicylic acid in ulcerative colitis

F. Dallegri, L. Ottonello, A. Ballestrero, F. Bogliolo, F. Ferrando, F. Patrone

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to investigate the effects of 5-aminosalicylic acid (5-ASA) on the cell injury mediated by activated neutrophils. We used a system constituted of neutrophils, triggered with phorbol myristate acetate, and 51Cr-labelled Daudi cells as targets. The results show that 5-ASA is capable of efficiently preventing neutrophil-mediated lysis. 5-ASA was up to 10-fold more effective than taurine, which acts as an hypochlorous acid scavenger. Moreover, 5-ASA was found to compete with taurine for the neutrophil derived hypochlorous acid. The results are consistent with the conclusion that 5-ASA is capable of limiting the neutrophil mediated cell damage by scavenging the generated hypochlorous acid. This may represent a potential mechanism for the therapeutic action of 5-ASA in ulcerative colitis.

Original languageEnglish
Pages (from-to)184-186
Number of pages3
JournalGut
Volume31
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Gastroenterology

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