Abstract
The aim of the present study was to investigate the effects of 5-aminosalicylic acid (5-ASA) on the cell injury mediated by activated neutrophils. We used a system constituted of neutrophils, triggered with phorbol myristate acetate, and 51Cr-labelled Daudi cells as targets. The results show that 5-ASA is capable of efficiently preventing neutrophil-mediated lysis. 5-ASA was up to 10-fold more effective than taurine, which acts as an hypochlorous acid scavenger. Moreover, 5-ASA was found to compete with taurine for the neutrophil derived hypochlorous acid. The results are consistent with the conclusion that 5-ASA is capable of limiting the neutrophil mediated cell damage by scavenging the generated hypochlorous acid. This may represent a potential mechanism for the therapeutic action of 5-ASA in ulcerative colitis.
| Original language | English |
|---|---|
| Pages (from-to) | 184-186 |
| Number of pages | 3 |
| Journal | Gut |
| Volume | 31 |
| Issue number | 2 |
| Publication status | Published - 1990 |
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ASJC Scopus subject areas
- Gastroenterology
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Cytoprotection against neutrophil derived hypochlorous acid : A potential mechanism for the therapeutic action of 5-aminosalicylic acid in ulcerative colitis. / Dallegri, F.; Ottonello, L.; Ballestrero, A.; Bogliolo, F.; Ferrando, F.; Patrone, F.
In: Gut, Vol. 31, No. 2, 1990, p. 184-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytoprotection against neutrophil derived hypochlorous acid
T2 - A potential mechanism for the therapeutic action of 5-aminosalicylic acid in ulcerative colitis
AU - Dallegri, F.
AU - Ottonello, L.
AU - Ballestrero, A.
AU - Bogliolo, F.
AU - Ferrando, F.
AU - Patrone, F.
PY - 1990
Y1 - 1990
N2 - The aim of the present study was to investigate the effects of 5-aminosalicylic acid (5-ASA) on the cell injury mediated by activated neutrophils. We used a system constituted of neutrophils, triggered with phorbol myristate acetate, and 51Cr-labelled Daudi cells as targets. The results show that 5-ASA is capable of efficiently preventing neutrophil-mediated lysis. 5-ASA was up to 10-fold more effective than taurine, which acts as an hypochlorous acid scavenger. Moreover, 5-ASA was found to compete with taurine for the neutrophil derived hypochlorous acid. The results are consistent with the conclusion that 5-ASA is capable of limiting the neutrophil mediated cell damage by scavenging the generated hypochlorous acid. This may represent a potential mechanism for the therapeutic action of 5-ASA in ulcerative colitis.
AB - The aim of the present study was to investigate the effects of 5-aminosalicylic acid (5-ASA) on the cell injury mediated by activated neutrophils. We used a system constituted of neutrophils, triggered with phorbol myristate acetate, and 51Cr-labelled Daudi cells as targets. The results show that 5-ASA is capable of efficiently preventing neutrophil-mediated lysis. 5-ASA was up to 10-fold more effective than taurine, which acts as an hypochlorous acid scavenger. Moreover, 5-ASA was found to compete with taurine for the neutrophil derived hypochlorous acid. The results are consistent with the conclusion that 5-ASA is capable of limiting the neutrophil mediated cell damage by scavenging the generated hypochlorous acid. This may represent a potential mechanism for the therapeutic action of 5-ASA in ulcerative colitis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025276189&partnerID=8YFLogxK
M3 - Article
C2 - 2155862
AN - SCOPUS:0025276189
VL - 31
SP - 184
EP - 186
JO - Gut
JF - Gut
SN - 0017-5749
IS - 2
ER -