Cytoreductive debulking surgery among patients with neuroendocrine liver metastasis: A multi-institutional analysis

A Ejaz, BN Reames, S Maithel, GA Poultsides, TW Bauer, RC Fields, MJ Weiss, HP Marques, L Aldrighetti, TM Pawlik

Research output: Contribution to journalArticle

Abstract

Background: Management of neuroendocrine liver metastasis (NELM) in the setting of unresectable disease is poorly defined and the role of debulking remains controversial. The objective of the current study was to define outcomes following non-curative intent liver-directed therapy (debulking) among patients with NELM. Methods: 612 patients were identified who underwent liver-directed therapy of NELM from a multi-institutional database. Outcomes were stratified according to curative (R0/R1) versus non-curative ≥ 80% debulking (R2). Results: 179 (29.2%) patients had an R2/debulking procedure. Patients undergoing debulking more commonly had more aggressive high-grade tumors (R0/R1: 12.8% vs. R2: 35.0%; P < 0.001) or liver disease burden that was bilateral (R0/R1: 52.8% vs. R2: 75.6%; P < 0.001). After a median follow-up of 51 months, median (R0/R1: not reached vs. R2: 87 months; P < 0.001) and 5-year survival (R0/R1: 85.2% vs. R2: 60.7%; P < 0.001) was higher among patients who underwent an R0/R1 resection compared with patients who underwent a debulking operation. Among patients with ≥50% NELM liver involvement, median and 5-year survival following debulking was 55.4 months and 40.6%, respectively. Conclusion: Debulking operations for NELM provided reasonable long-term survival. Hepatic debulking for patients with NELM is a reasonable therapeutic option for patients with grossly unresectable disease that may provide a survival benefit. © 2017.
Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalHPB
Volume20
Issue number3
DOIs
Publication statusPublished - 2018

Fingerprint Dive into the research topics of 'Cytoreductive debulking surgery among patients with neuroendocrine liver metastasis: A multi-institutional analysis'. Together they form a unique fingerprint.

  • Cite this

    Ejaz, A., Reames, BN., Maithel, S., Poultsides, GA., Bauer, TW., Fields, RC., Weiss, MJ., Marques, HP., Aldrighetti, L., & Pawlik, TM. (2018). Cytoreductive debulking surgery among patients with neuroendocrine liver metastasis: A multi-institutional analysis. HPB, 20(3), 277-284. https://doi.org/10.1016/j.hpb.2017.08.039