Cytoreductive Partial Nephrectomy Does Not Undermine Cancer Control in Metastatic Renal Cell Carcinoma: A Population-Based Study

Umberto Capitanio, Laurent Zini, Paul Perrotte, Shahrokh F. Shariat, Claudio Jeldres, Philippe Arjane, Daniel Pharand, Hugues Widmer, François Péloquin, Francesco Montorsi, Jean Jacques Patard, Pierre I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We examined the population-based rates of cancer-specific survival in patients with metastatic renal cell carcinoma (MRCC) treated with either partial (PN) or radical cytoreductive nephrectomy (RN). Methods: Patients diagnosed with MRCC and treated with either PN or RN were identified within nine SEER cancer registries. Matched and unmatched Kaplan-Meier survival analyses, as well as multivariable Cox regression models compared the effect of RN (n = 1997, 97.8%) vs. PN (n = 46, 2.2%) on cancer-specific survival (CSS). Covariates consisted of age, gender, community type (rural vs urban), race, Surveillance, Epidemiology, and End Results (SEER) registry, tumor size and year of diagnosis. Results: In multivariable unmatched Cox regression analyses, no statistically significantly difference was found in CSS between the two groups (hazard ratio [HR] 1.40, P = .16). Similarly, no difference in CSS was found in the matched analyses (HR 1.35, log rank P = .34). Conclusion: Cytoreductive PN does not appear to undermine survival in patients with MRCC.

Original languageEnglish
Pages (from-to)1090-1095
Number of pages6
JournalUrology
Volume72
Issue number5
DOIs
Publication statusPublished - Nov 2008

ASJC Scopus subject areas

  • Urology

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