Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in a patient with peritoneal mesothelioma and HIV infection

Maria Rosaria Balestra, Dario Baratti, Fulvio Crippa, Barbara Laterza, Shigeki Kusamura, Martin Langer, Marcello Deraco

Research output: Contribution to journalArticle

Abstract

Background. High rates of septic complications have been associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, which has been suggested as the treatment of choice for isolated peritoneal malignancies. Patients infected by the human immunodeficiency virus (HIV) are still considered at a high operative risk. Method. A 58-year-old man with HIV infection and diffuse peritoneal mesothelioma underwent optimal cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Results. The patient experienced a complete clinical response to therapy with no adverse effect on disease course or markers for HIV (CD4 count, beta2-microglobulin, neopterin, p24 antigen, and viral load). Conclusion. This report suggests that this innovative approach can be successfully performed also in this clinical setting. In selected patients who respond to all criteria, surgery is possible and is a safe and effective therapeutic option.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalTumori
Volume96
Issue number2
Publication statusPublished - Mar 2010

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Mesothelioma
Virus Diseases
HIV
Drug Therapy
Neopterin
CD4 Lymphocyte Count
Viral Load
Therapeutics
Antigens
Neoplasms

Keywords

  • AIDS
  • Peritoneal carcinomatosis
  • Peritonectomy
  • Surgical complications

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in a patient with peritoneal mesothelioma and HIV infection. / Balestra, Maria Rosaria; Baratti, Dario; Crippa, Fulvio; Laterza, Barbara; Kusamura, Shigeki; Langer, Martin; Deraco, Marcello.

In: Tumori, Vol. 96, No. 2, 03.2010, p. 340-344.

Research output: Contribution to journalArticle

Balestra, Maria Rosaria ; Baratti, Dario ; Crippa, Fulvio ; Laterza, Barbara ; Kusamura, Shigeki ; Langer, Martin ; Deraco, Marcello. / Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in a patient with peritoneal mesothelioma and HIV infection. In: Tumori. 2010 ; Vol. 96, No. 2. pp. 340-344.
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