Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer

L. Miglietta, L. Canobbio, F. Boccardo

Research output: Contribution to journalArticlepeer-review


The authors review the data and knowledge concerning the problem of secondary hormone non responsiveness of advanced prostatic carcinoma after hormone manipulation. They list the mechanisms of this hormone non responsiveness and examine the reasons why the standard chemotherapy is not efficacious as in other solid tumors. The difficulties of administering chemotherapy in patients with hormone escaped prostatic carcinoma are also pointed out (decrease of bone marrow reserve, poor general condition, renal impairment, etc.).

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalActa Urologica Italica
Issue number5
Publication statusPublished - 1995


  • chemotherapy
  • hormone escaped prostatic carcinoma

ASJC Scopus subject areas

  • Urology


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