Cytotoxic effect in vitro and tumour volume reduction in vivo induced by chemotherapeutic agents

L. Morasca, G. Balconi, E. Erba, P. Lelieveld, L. M. Van Putten

Research output: Contribution to journalArticlepeer-review

Abstract

By a comparison of in vitro and in vivo effectiveness of cytostatic agents on a transplantable mouse osteosarcoma, a number of drugs were identified for which the in vitro response is not a good prediction for the in vivo response. For a number of such discrepancies, explanations have been identified or tentatively been put forward, namely: 1. (1) absence in vitro of drug metabolizing systems which are effective in vivo. 2. (2) too low tumour drug levels reached by safe drug doses; 3. (3) too short duration of effective drug levels after single dose in vivo. For a number of drugs, unidentified factors cause such discrepancies. However, there is another group of widely used cytostatic agents for which an in vitro test may give a good prediction of overall tumour response and further studies seem to confirm this for other types of tumours.

Original languageEnglish
Pages (from-to)667-671
Number of pages5
JournalEuropean Journal of Cancer (1965)
Volume10
Issue number10
DOIs
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Oncology

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