TY - JOUR
T1 - Cytotoxic effect in vitro and tumour volume reduction in vivo induced by chemotherapeutic agents
AU - Morasca, L.
AU - Balconi, G.
AU - Erba, E.
AU - Lelieveld, P.
AU - Van Putten, L. M.
PY - 1974
Y1 - 1974
N2 - By a comparison of in vitro and in vivo effectiveness of cytostatic agents on a transplantable mouse osteosarcoma, a number of drugs were identified for which the in vitro response is not a good prediction for the in vivo response. For a number of such discrepancies, explanations have been identified or tentatively been put forward, namely: 1. (1) absence in vitro of drug metabolizing systems which are effective in vivo. 2. (2) too low tumour drug levels reached by safe drug doses; 3. (3) too short duration of effective drug levels after single dose in vivo. For a number of drugs, unidentified factors cause such discrepancies. However, there is another group of widely used cytostatic agents for which an in vitro test may give a good prediction of overall tumour response and further studies seem to confirm this for other types of tumours.
AB - By a comparison of in vitro and in vivo effectiveness of cytostatic agents on a transplantable mouse osteosarcoma, a number of drugs were identified for which the in vitro response is not a good prediction for the in vivo response. For a number of such discrepancies, explanations have been identified or tentatively been put forward, namely: 1. (1) absence in vitro of drug metabolizing systems which are effective in vivo. 2. (2) too low tumour drug levels reached by safe drug doses; 3. (3) too short duration of effective drug levels after single dose in vivo. For a number of drugs, unidentified factors cause such discrepancies. However, there is another group of widely used cytostatic agents for which an in vitro test may give a good prediction of overall tumour response and further studies seem to confirm this for other types of tumours.
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U2 - 10.1016/0014-2964(74)90006-1
DO - 10.1016/0014-2964(74)90006-1
M3 - Article
C2 - 4533898
AN - SCOPUS:0016335276
VL - 10
SP - 667
EP - 671
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 10
ER -