Cytotoxic effect of the association of BCNU with Rhein or Lonidamine on a human glioma cell line

A. Floridi, P. F. Gentile, T. Bruno, M. Fanciulli, M. G. Paggi, M. Zeuli, M. Benassi

Research output: Contribution to journalArticle

Abstract

The effect of association of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU)-Rhein (RH) and BCNU-Lonidamine (LND) on the clonogenic activity of human glioma cells was evaluated. Both RH and LND modulate the lethal effect of BCNU regardless of the schedule of treatment. The analysis of the interactions, performed with the isbolar method according to Berembaum, demonstrates an additivity of the effects. The possible mechanisms as well as the implications for the design of brain tumor schedule treatment are discussed.

Original languageEnglish
Pages (from-to)789-792
Number of pages4
JournalAnticancer Research
Volume11
Issue number2
Publication statusPublished - 1991

Keywords

  • BCNU
  • cytotoxic effect
  • human glioma cell line
  • Lonidamine
  • Rhein

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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