Cytotoxic effector function of B lymphoblasts

L. Bersani, F. Colotta, G. Peri, A. Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

EBV-transformed B lymphoblastoid cell lines and clones were cytotoxic in vitro against Actinomycin D-pretreated WEHI 164 sarcoma cells, a system in which mononuclear phagocytes were previously identified as effectors. Similarly, unlike resting B cells, normal B lymphoblasts stimulated for 72 hr with Staphylococcus aureus Cowan I and purified according to the expression of the B cell surface marker B1, demonstrated appreciable cytolytic activity. B lymphoblastoid cells and derived supernatants were cytotoxic for Actinomycin D-pretreated WEHI 164 cells, and killing was inhibited by an antilymphotoxin but not an anti-tumor necrosis factor antiserum. Thus, B lymphoblasts have cytotoxic potential, mediated by lymphotoxin or a lymphotoxin-like soluble product.

Original languageEnglish
Pages (from-to)645-648
Number of pages4
JournalJournal of Immunology
Volume139
Issue number2
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

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