Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus

Angela Perrone, Alberto Plaza, Elena Bloise, Patrizia Nigro, Arafa I. Hamed, Maria Antonietta Belisario, Cosimo Pizza, Sonia Piacente

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Two new furostanol saponins, (25R)-26-O-β-D-glucopyranosyl-5α- furostan-2α,3β,22α,26-tetraol 3-O-{β-D-galactopyranosyl- (1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl- (1→4)-β-D-galactopyranoside} (1) and (25R)-26-O-β-D- glucopyranosyl-5α-furostan-3β,22α,26-triol 3-O-{β-D- galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)] -O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside} (2), and their O-methyl derivatives (3 and 4), and a new megastigmane glucoside, (6S,7E,9ξ)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 10-O-β-D- glucopyranoside (6), along with one known spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis. The cytotoxic activities of 1-6 against U937, MCF7, and HepG2 cells were evaluated. Compounds 2 (IC50 0.5 μM) and 5 (IC50 0.1 μM) showed the highest activity against U937 cells.

Original languageEnglish
Pages (from-to)1549-1553
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number10
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Tribulus
norisoprenoids
U937 Cells
Saponins
Glucosides
saponins
Galactose
Inhibitory Concentration 50
glucosides
inhibitory concentration 50
Spirostans
Spectroscopic analysis
MCF-7 Cells
Hep G2 Cells
aerial parts
cells
Antennas
Derivatives
megastigmane

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Perrone, A., Plaza, A., Bloise, E., Nigro, P., Hamed, A. I., Belisario, M. A., ... Piacente, S. (2005). Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus. Journal of Natural Products, 68(10), 1549-1553. https://doi.org/10.1021/np0502138

Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus. / Perrone, Angela; Plaza, Alberto; Bloise, Elena; Nigro, Patrizia; Hamed, Arafa I.; Belisario, Maria Antonietta; Pizza, Cosimo; Piacente, Sonia.

In: Journal of Natural Products, Vol. 68, No. 10, 10.2005, p. 1549-1553.

Research output: Contribution to journalArticle

Perrone, A, Plaza, A, Bloise, E, Nigro, P, Hamed, AI, Belisario, MA, Pizza, C & Piacente, S 2005, 'Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus', Journal of Natural Products, vol. 68, no. 10, pp. 1549-1553. https://doi.org/10.1021/np0502138
Perrone A, Plaza A, Bloise E, Nigro P, Hamed AI, Belisario MA et al. Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus. Journal of Natural Products. 2005 Oct;68(10):1549-1553. https://doi.org/10.1021/np0502138
Perrone, Angela ; Plaza, Alberto ; Bloise, Elena ; Nigro, Patrizia ; Hamed, Arafa I. ; Belisario, Maria Antonietta ; Pizza, Cosimo ; Piacente, Sonia. / Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus. In: Journal of Natural Products. 2005 ; Vol. 68, No. 10. pp. 1549-1553.
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