Abstract
Two new furostanol saponins, (25R)-26-O-β-D-glucopyranosyl-5α- furostan-2α,3β,22α,26-tetraol 3-O-{β-D-galactopyranosyl- (1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl- (1→4)-β-D-galactopyranoside} (1) and (25R)-26-O-β-D- glucopyranosyl-5α-furostan-3β,22α,26-triol 3-O-{β-D- galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)] -O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside} (2), and their O-methyl derivatives (3 and 4), and a new megastigmane glucoside, (6S,7E,9ξ)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 10-O-β-D- glucopyranoside (6), along with one known spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis. The cytotoxic activities of 1-6 against U937, MCF7, and HepG2 cells were evaluated. Compounds 2 (IC50 0.5 μM) and 5 (IC50 0.1 μM) showed the highest activity against U937 cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1549-1553 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 68 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2005 |
Fingerprint
ASJC Scopus subject areas
- Plant Science
- Chemistry (miscellaneous)
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus. / Perrone, Angela; Plaza, Alberto; Bloise, Elena; Nigro, Patrizia; Hamed, Arafa I.; Belisario, Maria Antonietta; Pizza, Cosimo; Piacente, Sonia.
In: Journal of Natural Products, Vol. 68, No. 10, 10.2005, p. 1549-1553.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cytotoxic furostanol saponins and a megastigmane glucoside from Tribulus parvispinus
AU - Perrone, Angela
AU - Plaza, Alberto
AU - Bloise, Elena
AU - Nigro, Patrizia
AU - Hamed, Arafa I.
AU - Belisario, Maria Antonietta
AU - Pizza, Cosimo
AU - Piacente, Sonia
PY - 2005/10
Y1 - 2005/10
N2 - Two new furostanol saponins, (25R)-26-O-β-D-glucopyranosyl-5α- furostan-2α,3β,22α,26-tetraol 3-O-{β-D-galactopyranosyl- (1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl- (1→4)-β-D-galactopyranoside} (1) and (25R)-26-O-β-D- glucopyranosyl-5α-furostan-3β,22α,26-triol 3-O-{β-D- galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)] -O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside} (2), and their O-methyl derivatives (3 and 4), and a new megastigmane glucoside, (6S,7E,9ξ)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 10-O-β-D- glucopyranoside (6), along with one known spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis. The cytotoxic activities of 1-6 against U937, MCF7, and HepG2 cells were evaluated. Compounds 2 (IC50 0.5 μM) and 5 (IC50 0.1 μM) showed the highest activity against U937 cells.
AB - Two new furostanol saponins, (25R)-26-O-β-D-glucopyranosyl-5α- furostan-2α,3β,22α,26-tetraol 3-O-{β-D-galactopyranosyl- (1→2)-O-[β-D-xylopyranosyl-(1→3)]-O-β-D-glucopyranosyl- (1→4)-β-D-galactopyranoside} (1) and (25R)-26-O-β-D- glucopyranosyl-5α-furostan-3β,22α,26-triol 3-O-{β-D- galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)] -O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside} (2), and their O-methyl derivatives (3 and 4), and a new megastigmane glucoside, (6S,7E,9ξ)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 10-O-β-D- glucopyranoside (6), along with one known spirostanol saponin, gitonin (5), and four known megastigmane glucosides were isolated from the aerial parts of Tribulus parvispinus. Their structures were established by detailed spectroscopic analysis. The cytotoxic activities of 1-6 against U937, MCF7, and HepG2 cells were evaluated. Compounds 2 (IC50 0.5 μM) and 5 (IC50 0.1 μM) showed the highest activity against U937 cells.
UR - http://www.scopus.com/inward/record.url?scp=27844610230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27844610230&partnerID=8YFLogxK
U2 - 10.1021/np0502138
DO - 10.1021/np0502138
M3 - Article
C2 - 16252924
AN - SCOPUS:27844610230
VL - 68
SP - 1549
EP - 1553
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 10
ER -