Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells

Loredana Falzano, Maria Giovanna Quaranta, Sara Travaglione, Perla Filippini, Alessia Fabbri, Marina Viora, Gianfranco Donelli, Carla Fiorentini

Research output: Contribution to journalArticle

Abstract

Uropathogenic Escherichia coli strains frequently produce a Rho-activating protein toxin named cytotoxic necrotizing factor type 1 (CNF1). We herein report that CNF1 promotes transcription and release of tumor necrosis factor alpha, gamma interferon, interleukin-6 (IL-6), and IL-8 proinflammatory cytokines and increases the production of reactive oxygen species (ROS) in uroepithelial T24 cells. The antioxidant N-acetyl-L-cysteine counteracts these phenomena, a fact which suggests a role for ROS-mediated signaling in CNF1-induced proinflammatory cytokine production.

Original languageEnglish
Pages (from-to)4178-4181
Number of pages4
JournalInfection and Immunity
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

ASJC Scopus subject areas

  • Immunology

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