Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells

Loredana Falzano, Maria Giovanna Quaranta, Sara Travaglione, Perla Filippini, Alessia Fabbri, Marina Viora, Gianfranco Donelli, Carla Fiorentini

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Uropathogenic Escherichia coli strains frequently produce a Rho-activating protein toxin named cytotoxic necrotizing factor type 1 (CNF1). We herein report that CNF1 promotes transcription and release of tumor necrosis factor alpha, gamma interferon, interleukin-6 (IL-6), and IL-8 proinflammatory cytokines and increases the production of reactive oxygen species (ROS) in uroepithelial T24 cells. The antioxidant N-acetyl-L-cysteine counteracts these phenomena, a fact which suggests a role for ROS-mediated signaling in CNF1-induced proinflammatory cytokine production.

Original languageEnglish
Pages (from-to)4178-4181
Number of pages4
JournalInfection and Immunity
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 1 2003

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Reactive Oxygen Species
Cytokines
Uropathogenic Escherichia coli
Acetylcysteine
Interleukin-8
Interferon-alpha
Interferon-gamma
Interleukin-6
Tumor Necrosis Factor-alpha
Antioxidants
cytotoxic necrotizing factor type 1
Proteins

ASJC Scopus subject areas

  • Immunology

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Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells. / Falzano, Loredana; Quaranta, Maria Giovanna; Travaglione, Sara; Filippini, Perla; Fabbri, Alessia; Viora, Marina; Donelli, Gianfranco; Fiorentini, Carla.

In: Infection and Immunity, Vol. 71, No. 7, 01.07.2003, p. 4178-4181.

Research output: Contribution to journalArticle

Falzano, Loredana ; Quaranta, Maria Giovanna ; Travaglione, Sara ; Filippini, Perla ; Fabbri, Alessia ; Viora, Marina ; Donelli, Gianfranco ; Fiorentini, Carla. / Cytotoxic necrotizing factor 1 enhances reactive oxygen species-dependent transcription and secretion of proinflammatory cytokines in human uroepithelial cells. In: Infection and Immunity. 2003 ; Vol. 71, No. 7. pp. 4178-4181.
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