Cytotoxic T-cell and NK-cell lymphomas: Current questions and controversies

Steven H. Swerdlow, Elaine S. Jaffe, Pierre Brousset, John K C Chan, Laurence de Leval, Philippe Gaulard, Nancy Lee Harris, Stefano Pileri, Lawrence M. Weiss

Research output: Contribution to journalArticle

Abstract

The cytotoxic T-cell and natural killer (NK)-cell lymphomas and related disorders are important but relatively rare lymphoid neoplasms that frequently are a challenge for practicing pathologists. This selective review, based on a meeting of the International Lymphoma Study Group, briefly reviews T-cell and NK-cell development and addresses questions related to the importance of precise cell lineage (αβ-type T cell, γδ T cell, or NK cell), the implications of Epstein-Barr virus infection, the significance of anatomic location including nodal disease, and the question of further categorization of enteropathy-associated T-cell lymphomas. Finally, developments subsequent to the 2008 World Health Organization Classification, including the recognition of indolent NK-cell and T-cell disorders of the gastrointestinal tract are presented.

Original languageEnglish
JournalAmerican Journal of Surgical Pathology
DOIs
Publication statusAccepted/In press - Jul 14 2014

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine
  • Anatomy

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    Swerdlow, S. H., Jaffe, E. S., Brousset, P., Chan, J. K. C., de Leval, L., Gaulard, P., Harris, N. L., Pileri, S., & Weiss, L. M. (Accepted/In press). Cytotoxic T-cell and NK-cell lymphomas: Current questions and controversies. American Journal of Surgical Pathology. https://doi.org/10.1097/PAS.0000000000000295