Cytotoxicity and DNA damage caused by 4-demethoxydaunorubicin and its metabolite 4-demethoxy-13-hydroxydaunorubicin in human acute myeloid leukemia cells

Monica Limonta, Andrea Biondi, Giovanni Giudici, Giorgina Specchia, Carlo Catapano, Giuseppe Masera, Tiziano Barbui, Maurizio D'Incalci

Research output: Contribution to journalArticle

Abstract

4-Demethoxydaunorubicin (4-DMDR) and its major metabolite 4-demethoxy-13-hydroxydaunorubicin (4-DMDRol) were investigated for their cytotoxicity and mode of action against human leukemic cells. The drug and its metabolite appeared to be equally potent as both inhibitors of cell proliferation and inducers of DNA double-strand breaks in the OCI AML-3 cell line and cells derived directly from patients with acute myeloid leukemia (AML). This suggests that 4-DMDRol plays an important role in the antileukemic activity of 4-DMDR.

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume26
Issue number5
DOIs
Publication statusPublished - Sep 1990

ASJC Scopus subject areas

  • Pharmacology
  • Oncology
  • Cancer Research

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