Cytotoxicity and internalization analysis of silicon nanowires in Buffalo Green Monkey cells: A preliminary study to evaluate the possibility of carrying viruses inside the cells

Roberta Condò, Mariantonietta Leo, Luca Maiolo, Annalisa Convertino, Federica Sinibaldi, Roberto Santucci, Andrea Divizia, Vincenzo Campanella, Giuseppina La Rosa, Alfredo Colantoni, Maurizio Anselmi, Maurizio Divizia

Research output: Contribution to journalArticlepeer-review

Abstract

Silicon nanowires (SiNWs) are attractive functional nanomaterials for biomedical applications. The ability to easily tune their size and density, potential biocompatibility, and knowledge of the chemical activation of SiNWs surface make them natural tools to interact with biological materials. We evaluated the possibility of exploiting SiNWs as carriers to introduce organic compounds into cells. The cellular toxicity and the internalization capacity of free-standing and label-free SiNWs were tested on Buffalo Green Monkey cells (BGM). Confocal fluorescent observation of SiNWs conjugated with fluorescein-polyethylene imine (PEI) confirmed the internalization of the NWs into the Buffalo Green Monkey Cells (BGM).

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalNew Microbiologica
Volume43
Issue number1
Publication statusPublished - Jan 2020

Keywords

  • Cytotoxicity
  • Fluorescein
  • Polyethylene imine
  • Silicon nanowires

ASJC Scopus subject areas

  • Microbiology (medical)

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