Cytotoxicity in vitro and preliminary antitumor activity in vivo of a novel organotin compound

Federica Barbieri, Maurizio Viale, Fabio Sparatore, Anna Favre, Monica Cagnoli, Cristina Bruzzo, Federica Novelli, Angela Alama

Research output: Contribution to journalArticle

Abstract

The cytotoxic effect and antitumor activity induced by the novel organotin compound triethyltin(lV)lupinylsulfide hydrochloride, have been investigated. Different patterns of antiproliferative effects have been observed in a panel of human tumor cell lines in vitro. Toxicity studies in mice reported acute toxicity at the doses of 21 and 17.5 mg/kg which progressively disappeared at lower concentrations. On this basis, the doses of 3.5, 7 and 14 mg/kg were selected to assess the antitumor activity in vivo against the P388 leukemic cells xenografted in mice. This compound was able to induce a dose-dependent significant reduction of tumor volume, up to 46%, at the highest concentration (p = 0.0062) without important toxicity, as also confirmed by histological analysis of the main organ tissues. This preliminary study seems to hold interest for further investigations in different tumor models as well as for the evaluation of optimal drug route and schedule.

Original languageEnglish
Pages (from-to)977-980
Number of pages4
JournalAnticancer Research
Volume20
Issue number2 A
Publication statusPublished - 2000

Keywords

  • Antitumor activity
  • Cytotoxicity
  • Tin compound

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Cytotoxicity in vitro and preliminary antitumor activity in vivo of a novel organotin compound'. Together they form a unique fingerprint.

  • Cite this

    Barbieri, F., Viale, M., Sparatore, F., Favre, A., Cagnoli, M., Bruzzo, C., Novelli, F., & Alama, A. (2000). Cytotoxicity in vitro and preliminary antitumor activity in vivo of a novel organotin compound. Anticancer Research, 20(2 A), 977-980.