Cytotoxicity of PMMA-based nanoparticles synthesized adopting SDS and Tween 80

Claudio Colombo, Monica Lupi, Paolo Ubezio, Davide Moscatelli

Research output: Contribution to journalArticle

Abstract

Summary: in this work the cytotoxicity of PMMA-based nanoparticles against mouse mammary cancer cells (4T1) has been investigated. NPs have been synthesized using either monomer starved semi-batch emulsion polymerization (MSSEP) or standard batch emulsion polymerization (BEP) processes adopting potassium persulfate (KPS) as initiator and two different emulsifiers: sodium dodecyl sulfate (SDS) and Tween 80. The toxicity of NPs produced using SDS has been confirmed in in vitro experiments while it has been found that NPs stabilized with Tween 80 show a good biocompatibility. Moreover, the absence of toxicity of NPs in which the SDS is substituted with Tween 80 adopting ion exchange resins (IER) has been proved. Finally the biocompatibility of the sulfate chain end groups coming from the adopted initiator has been assessed.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalMacromolecular Symposia
Volume324
Issue number1
DOIs
Publication statusPublished - Feb 2013

Keywords

  • biocompatibility
  • nanoparticles
  • PMMA
  • SDS
  • surfactants

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics
  • Condensed Matter Physics

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