Cytotoxic/natural killer cell cutaneous lymphomas: Report of the EORTC Cutaneous Lymphoma Task Force workshop

Marco Santucci, Nicola Pimpinelli, Daniela Massi, Marshall E. Kadin, Chris J L M Meijer, Hans Konrad Müller-Hermelink, Marco Paulli, Janine Wechsler, Rein Willemze, Heike Audring, Maria Grazia Bernengo, Lorenzo Cerroni, Sergio Chimenti, Andreas Chott, José L. Diaz-Pérez, Edgard Dippel, Lyn M. Duncan, Alfred C. Feller, Marie Louise Geerts, Christian HallermannWerner Kempf, Robin Russell-Jones, Christian Sander, Emilio Berti

Research output: Contribution to journalArticlepeer-review


BACKGROUND. Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent a group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature and classification. METHODS. This study analyzes 48 cases of primary cutaneous lymphoma expressing cytotoxic proteins and/or the NK cell marker, CD56. These cases were collected for a workshop of the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Task Force, to better clarify the clinical, morphologic, and phenotypic features of these uncommon tumors. RESULTS. Several categories with different clinical and pathologic features were delineated: 1) aggressive, CD8+, epidermotropic, cytotoxic T-cell lymphoma; 2) mycosis fungoides, cytotoxic immunophenotype variant; 3) subcutaneous panniculitis-like T-cell lymphoma; 4) NK/T-cell lymphoma, nasal type; 5) CD4+, NK cell lymphoma; 6) blastoid NK cell lymphoma; (7) intravascular NK-like lymphoma; and 8) cytotoxic, peripheral T-cell lymphoma. CONCLUSIONS. Our data show that primary cutaneous cytotoxic/NK cell lymphomas include distinct groups of diseases, clinically, histologically, and biologically. Because the finding of a cytotoxic phenotype often has prognostic significance, the routine use of cytotoxic markers in the diagnosis and classification of cutaneous lymphomas should be expanded.

Original languageEnglish
Pages (from-to)610-627
Number of pages18
Issue number3
Publication statusPublished - Feb 1 2003


  • CD56
  • Classification
  • Cytotoxic/NK cell lymphomas
  • Prognosis
  • Skin
  • Therapy
  • TIA-1

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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