d-α-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties

A. Tasinato, D. Boscoboinik, G. M. Bartoli, P. Maroni, A. Azzi

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

d-α-Tocopherol, but not d-β-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations. d-α-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-β-tocopherol is ineffective. Furthermore d-β-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-α-tocopherol. The negative regulation by d-α-tocopherol of PKC activity appears to be the cause and not the effect of smooth muscle cell growth inhibition. d-α-Tocopherol does not act by binding to PKC directly but presumably by preventing PKC activation. It is concluded that, in vascular smooth muscle cells, d-α-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction pathway regulating cell proliferation.

Original languageEnglish
Pages (from-to)12190-12194
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number26
Publication statusPublished - Dec 19 1995

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Tocopherols
Vascular Smooth Muscle
Protein Kinase C
Smooth Muscle Myocytes
Antioxidants
Cell Proliferation
Growth
Signal Transduction
Carrier Proteins

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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title = "d-α-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties",
abstract = "d-α-Tocopherol, but not d-β-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations. d-α-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-β-tocopherol is ineffective. Furthermore d-β-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-α-tocopherol. The negative regulation by d-α-tocopherol of PKC activity appears to be the cause and not the effect of smooth muscle cell growth inhibition. d-α-Tocopherol does not act by binding to PKC directly but presumably by preventing PKC activation. It is concluded that, in vascular smooth muscle cells, d-α-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction pathway regulating cell proliferation.",
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T1 - d-α-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties

AU - Tasinato, A.

AU - Boscoboinik, D.

AU - Bartoli, G. M.

AU - Maroni, P.

AU - Azzi, A.

PY - 1995/12/19

Y1 - 1995/12/19

N2 - d-α-Tocopherol, but not d-β-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations. d-α-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-β-tocopherol is ineffective. Furthermore d-β-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-α-tocopherol. The negative regulation by d-α-tocopherol of PKC activity appears to be the cause and not the effect of smooth muscle cell growth inhibition. d-α-Tocopherol does not act by binding to PKC directly but presumably by preventing PKC activation. It is concluded that, in vascular smooth muscle cells, d-α-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction pathway regulating cell proliferation.

AB - d-α-Tocopherol, but not d-β-tocopherol, negatively regulates proliferation of vascular smooth muscle cells at physiological concentrations. d-α-Tocopherol inhibits protein kinase C (PKC) activity, whereas d-β-tocopherol is ineffective. Furthermore d-β-tocopherol prevents the inhibition of cell growth and of PKC activity caused by d-α-tocopherol. The negative regulation by d-α-tocopherol of PKC activity appears to be the cause and not the effect of smooth muscle cell growth inhibition. d-α-Tocopherol does not act by binding to PKC directly but presumably by preventing PKC activation. It is concluded that, in vascular smooth muscle cells, d-α-tocopherol acts specifically through a nonantioxidant mechanism and exerts a negative control on a signal transduction pathway regulating cell proliferation.

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