Abstract
No tolerance to the anorectic activity of d-amphetamine was found in rats given two daily injections of 1.25 mg/kg for 28 days. Such rats also presented no changes in the number of binding sites for serotonin and catecholamines in various brain areas. A 28-day treatment with 10 mg/kg d-amphetamine twice daily caused a significant reduction in the number of binding sites for 3H-dihydroalprenolol (beta adrenergic receptor ligand) in hippocampus, and 3H-spiroperidol (dopamine receptor ligand) in striatum and nucleus accumbens. This treatment did not modify the anorectic effect of 1.25 mg/kg of amphetamine but it markedly reduced the motor hyperactivity induced by this treatment and completely blocked the stereotyped licking and biting induced by apomorphine. Amphetamine stereotypy was not significantly reduced but disappeared faster in chronically treated rats. The possible reasons for the different results (tolerance or sensitization) reported by various authors on changes in amphetamine's effects on motor behavior during chronic treatment are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 36-49 |
| Number of pages | 14 |
| Journal | Archives Internationales de Pharmacodynamie et de Therapie |
| Volume | 260 |
| Issue number | 1 |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats : Relationship with changes in the number of catecholamine receptor sites in the brain. / Bendotti, C.; Borsini, F.; Cotecchia, S.; De Blasi, A.; Mennini, T.; Samanin, R.
In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 260, No. 1, 1982, p. 36-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats
T2 - Relationship with changes in the number of catecholamine receptor sites in the brain
AU - Bendotti, C.
AU - Borsini, F.
AU - Cotecchia, S.
AU - De Blasi, A.
AU - Mennini, T.
AU - Samanin, R.
PY - 1982
Y1 - 1982
N2 - No tolerance to the anorectic activity of d-amphetamine was found in rats given two daily injections of 1.25 mg/kg for 28 days. Such rats also presented no changes in the number of binding sites for serotonin and catecholamines in various brain areas. A 28-day treatment with 10 mg/kg d-amphetamine twice daily caused a significant reduction in the number of binding sites for 3H-dihydroalprenolol (beta adrenergic receptor ligand) in hippocampus, and 3H-spiroperidol (dopamine receptor ligand) in striatum and nucleus accumbens. This treatment did not modify the anorectic effect of 1.25 mg/kg of amphetamine but it markedly reduced the motor hyperactivity induced by this treatment and completely blocked the stereotyped licking and biting induced by apomorphine. Amphetamine stereotypy was not significantly reduced but disappeared faster in chronically treated rats. The possible reasons for the different results (tolerance or sensitization) reported by various authors on changes in amphetamine's effects on motor behavior during chronic treatment are discussed.
AB - No tolerance to the anorectic activity of d-amphetamine was found in rats given two daily injections of 1.25 mg/kg for 28 days. Such rats also presented no changes in the number of binding sites for serotonin and catecholamines in various brain areas. A 28-day treatment with 10 mg/kg d-amphetamine twice daily caused a significant reduction in the number of binding sites for 3H-dihydroalprenolol (beta adrenergic receptor ligand) in hippocampus, and 3H-spiroperidol (dopamine receptor ligand) in striatum and nucleus accumbens. This treatment did not modify the anorectic effect of 1.25 mg/kg of amphetamine but it markedly reduced the motor hyperactivity induced by this treatment and completely blocked the stereotyped licking and biting induced by apomorphine. Amphetamine stereotypy was not significantly reduced but disappeared faster in chronically treated rats. The possible reasons for the different results (tolerance or sensitization) reported by various authors on changes in amphetamine's effects on motor behavior during chronic treatment are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020459748&partnerID=8YFLogxK
M3 - Article
C2 - 6962686
AN - SCOPUS:0020459748
VL - 260
SP - 36
EP - 49
JO - Archives Internationales de Pharmacodynamie et de Therapie
JF - Archives Internationales de Pharmacodynamie et de Therapie
SN - 0003-9780
IS - 1
ER -